Technology Process of (2R,3S,3aR,8bR)-8b-hydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1-oxo-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide
There total 28 articles about (2R,3S,3aR,8bR)-8b-hydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1-oxo-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
magnesium iodide;
In
diethyl ether; toluene;
at 90 ℃;
for 0.25h;
DOI:10.1002/anie.201501374
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: 1 h / -78 °C
2.1: selenium(IV) oxide; acetic acid / 1,4-dioxane / 0.5 h / Reflux
3.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 20 °C
4.1: magnesium iodide / toluene; diethyl ether / 0.25 h / 90 °C
With
selenium(IV) oxide; n-butyllithium; potassium tert-butylate; acetic acid; magnesium iodide;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; toluene;
DOI:10.1002/chem.201603312
- Guidance literature:
-
Multi-step reaction with 10 steps
2: 73 percent / DABCO, OsO4, NMO / tetrahydrofuran; H2O / Ambient temperature
3: C5H5N*SO3, (C2H5)3N / dimethylsulfoxide / Ambient temperature
4: (i-C3H7)2NC2H5 / benzene / Ambient temperature
5: H2 / 10percent Pd/C / ethanol / 760 Torr
6: NaH / tetrahydrofuran / Ambient temperature
7: MCPBA, NaHCO3 / CH2Cl2 / -20 °C
8: (CH3)3Al / benzene / 45 °C
9: H2 / PtO2 / ethanol / 760 Torr
10: KF / methanol / 40 °C
With
1,4-diaza-bicyclo[2.2.2]octane; potassium fluoride; osmium(VIII) oxide; N-methyl-2-indolinone; hydrogen; trimethylaluminum; sulfur trioxide pyridine complex; sodium hydride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
platinum(IV) oxide; palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; benzene;
DOI:10.1021/ja00180a081