3-{4-[Difluoro(4-trifluoromethylphenyl)methoxy]phenyl}-3-ethoxypropionic acid

Base Information

• Chemical Name: 3-{4-[Difluoro(4-trifluoromethylphenyl)methoxy]phenyl}-3-ethoxypropionic acid
• CAS No.: 1202575-46-9
• Molecular Formula: C₁₉H₁₇F₅O₄
• Molecular Weight: 404.334
• Mol file: 1202575-46-9.mol

Synonyms:3-{4-[Difluoro(4-trifluoromethylphenyl)methoxy]phenyl}-3-ethoxypropionic acid

Chemical Property of 3-{4-[Difluoro(4-trifluoromethylphenyl)methoxy]phenyl}-3-ethoxypropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{4-[Difluoro(4-trifluoromethylphenyl)methoxy]phenyl}-3-ethoxypropionic acid

There total 6 articles about 3-{4-[Difluoro(4-trifluoromethylphenyl)methoxy]phenyl}-3-ethoxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

3-{4-[difluoro(4-trifluoromethylphenyl)methoxy]phenyl}-3-ethoxypropionaldehyde → 3-{4-[Difluoro(4-trifluoromethylphenyl)methoxy]phenyl}-3-ethoxypropionic acid (1202575-46-9)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; In tetrahydrofuran; 2-methyl-but-2-ene; water; tert-butyl alcohol; at 20 ℃; for 3h;

Reference yield:

4-bromo-phenol (106-41-2) → 3-{4-[Difluoro(4-trifluoromethylphenyl)methoxy]phenyl}-3-ethoxypropionic acid (1202575-46-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 60 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.08 h / -78 °C

3.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 20 - 60 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4.2: 0.5 h / 20 °C

5.1: sodium chlorite; sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; tert-butyl alcohol; tetrahydrofuran / 3 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; 2-methyl-but-2-ene; hexane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

1-(chlorodifluoromethyl)-4-(trifluoromethyl)benzene (13947-94-9) → 3-{4-[Difluoro(4-trifluoromethylphenyl)methoxy]phenyl}-3-ethoxypropionic acid (1202575-46-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 60 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.08 h / -78 °C

3.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 20 - 60 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4.2: 0.5 h / 20 °C

5.1: sodium chlorite; sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; tert-butyl alcohol; tetrahydrofuran / 3 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; 2-methyl-but-2-ene; hexane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

4-bromo-phenol

1-(chlorodifluoromethyl)-4-(trifluoromethyl)benzene

(30A) 1-Bromo-4-[difluoro(4-trifluoromethylphenyl)methoxy]benzene

3-(tert-Butyldimethylsilyloxy)-1-{4-[difluoro-(4-trifluoromethylphenyl)methoxy]phenyl}propan-1-ol

Refernces