TETRAHYDROFURAN-2-ACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: TETRAHYDROFURAN-2-ACETIC ACID ETHYL ESTER
• CAS No.: 2434-02-8
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.197
• Hs Code.: 2932190090
• Mol file: 2434-02-8.mol

Synonyms:Ethyltetrahydrofuran-2-acetate;Tetrahydrofuran-2-acetic acid ethyl ester;

Chemical Property of TETRAHYDROFURAN-2-ACETIC ACID ETHYL ESTER

Chemical Property:

• Refractive Index: 1.4350-1.4390
• Boiling Point: 206.1 °C at 760 mmHg
• Flash Point: 89.3 °C
• PSA: 35.53000
• Density: 1.028 g/cm³
• LogP: 1.11860
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tetrahydro-2-furanaceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tetrahydro-2-furanacetic Acid Ethyl Ester is used in organic reactions for the opening of cyclic ethers using dimethylboron bromide.

Technology Process of TETRAHYDROFURAN-2-ACETIC ACID ETHYL ESTER

There total 11 articles about TETRAHYDROFURAN-2-ACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-2-(ethoxycarbonylmethylidene)tetrahydrofuran (99054-37-2) → ethyl tetrahydrofuran-2-acetate (2434-02-8,139456-82-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 48h;

DOI:10.1016/j.tet.2006.03.077

Reference yield: 95.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + diazoacetic acid ethyl ester (623-73-4) → ethyl tetrahydrofuran-2-acetate (2434-02-8,139456-82-9)

Guidance literature:

With copper(l) iodide; hydrotris(3-mesityl)pyrazolylborate thallium salt; In dichloromethane;

DOI:10.1021/ja016798j

Reference yield: 95.0%

(E)-3-(3-Bromo-propoxy)-acrylic acid ethyl ester → ethyl tetrahydrofuran-2-acetate (2434-02-8,139456-82-9)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 6h; Heating;

DOI:10.1016/S0040-4039(00)74101-3

upstream raw materials:

tetrahydrofuran

diazoacetic acid ethyl ester

4-butanolide

1-ethoxy-1-(tert-butyldimethylsilyloxy)ethene

Downstream raw materials:

hexahydro-2H-oxepin-2-one

6-Hydroxyhexanoic acid

methyl 6-hydroxycaproate

6-hydroxy-hexanoic acid ethyl ester

Refernces

• 1、 Maestre, Lourdes,Ozkal, Erhan,Ayats, Carles,Beltrn, lvaro,Daz-Requejo, M. Mar,Prez, Pedro J.,Perics, Miquel A.. "A fully recyclable heterogenized Cu catalyst for the general carbene transfer reaction in batch and flow". . p. 1510 - 1515. Retrieved 2015/02/05.
• 2、 Wang, Xiao Qing,Jia, Ping Jing,Liu, Su Ping,Yu, Wei. "TBAF-catalyzed cyclization of 6-hydroxyhex-2-ynoates and 7-hydroxyhept-2-ynoates". experimental part. p. 931 - 934. Retrieved 2012/01/11.