Levamlodipine nicotinate

Base Information

• Chemical Name: Levamlodipine nicotinate
• CAS No.: 675605-61-5
• Molecular Formula: C₆H₅NO₂*C₂₀H₂₅ClN₂O₅
• Molecular Weight: 531.993
• UNII: 7EQG8Y8AHW
• Mol file: 675605-61-5.mol

Synonyms:Levamlodipine nicotinate;7EQG8Y8AHW;(-)-AMLODIPINE NICOTINATE;3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-, 3-pyridinecarboxylate (1:1);3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-, mono-3-pyridinecarboxylate;675605-61-5;UNII-7EQG8Y8AHW;(s)-amlodipine nicotinate;SCHEMBL2255627;S Amlodipine Nicotinate [WHO-DD]

Chemical Property of Levamlodipine nicotinate

Chemical Property:

• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 11
• Exact Mass: 531.1772280
• Heavy Atom Count: 37
• Complexity: 760

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC(=CN=C1)C(=O)O
• Isomeric SMILES: CCOC(=O)C1=C(NC(=C([C@@H]1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC(=CN=C1)C(=O)O

Technology Process of Levamlodipine nicotinate

There total 1 articles about Levamlodipine nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.3%

nicotinic acid (59-67-6) + amlodipine (103129-82-4) → (S)-(-)-amlodipine nicotinate (675605-61-5)

Guidance literature:

In Petroleum ether; for 5h; Heating / reflux;

upstream raw materials:

nicotinic acid

amlodipine

Refernces