Z-L-ASPARTIC ACID 4-BENZYL 1-(4-NITROPHENYL) ESTER

Base Information

• Chemical Name: Z-L-ASPARTIC ACID 4-BENZYL 1-(4-NITROPHENYL) ESTER
• CAS No.: 2419-54-7
• Molecular Formula: C25H22 N2 O8
• Molecular Weight: 478.458
• Mol file: 2419-54-7.mol

Synonyms:Asparticacid, N-carboxy-, N,4-dibenzyl p-nitrophenyl ester, L- (6CI,7CI,8CI); a-p-Nitrophenyl b-benzylN-[(benzyloxy)carbonyl]-L-aspartate

Chemical Property of Z-L-ASPARTIC ACID 4-BENZYL 1-(4-NITROPHENYL) ESTER

Chemical Property:

• Vapor Pressure: 5.14E-18mmHg at 25°C
• Melting Point: 76 °C
• Refractive Index: 1.603
• Boiling Point: 673.8°C at 760 mmHg
• PKA: 10.08±0.46(Predicted)
• Flash Point: 361.3°C
• PSA: 140.24000
• Density: 1.332g/cm³
• LogP: 4.65630
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Z-Asp(OBzl)-ONp 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-L-ASPARTIC ACID 4-BENZYL 1-(4-NITROPHENYL) ESTER

There total 3 articles about Z-L-ASPARTIC ACID 4-BENZYL 1-(4-NITROPHENYL) ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + Z-Asp(OBzl)-OH (3479-47-8) → N-(benzyloxycarbonyl)-β-benzyl-L-aspartic acid p-nitrophenyl ester (2419-54-7)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1021/ja01079a018

Reference yield:

Z-Asp(OBzl)-OH (3479-47-8) + 4-Nitrophenyl chloroformate (7693-46-1) → N-(benzyloxycarbonyl)-β-benzyl-L-aspartic acid p-nitrophenyl ester (2419-54-7)

Guidance literature:

Multistep reaction; (i) DMF, (ii) /BRN= 2065292/, Et₃N;

Reference yield:

→ N-(benzyloxycarbonyl)-β-benzyl-L-aspartic acid p-nitrophenyl ester (2419-54-7)

Guidance literature:

Z-L-Asp-Bzl, p-Nitrophenol;

DOI:10.1021/ja00814a039

upstream raw materials:

4-nitro-phenol

Z-Asp(OBzl)-OH

4-Nitrophenyl chloroformate

Downstream raw materials:

(S)-3-Benzyloxycarbonylamino-N-[phenyl-((1R,2S,4S)-1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yloxycarbonyl)-methyl]-succinamic acid benzyl ester

(S)-3-Benzyloxycarbonylamino-N-[phenyl-((1S,2R,4R)-1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yloxycarbonyl)-methyl]-succinamic acid benzyl ester

N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D-phenylglycine (-)-α-fenchyl ester

L-aspartyl-D-phenylglycine (+)-endo-1,3,3-trimethyl-7-oxabicyclo<2.2.1>heptan-2-yl ester