α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid

Base Information

• Chemical Name: α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid
• CAS No.: 110862-44-7
• Molecular Formula: C₁₇H₂₂FNO₅
• Molecular Weight: 339.364
• Mol file: 110862-44-7.mol

Synonyms:α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid

Chemical Property of α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid

There total 5 articles about α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol hydrate (151900-28-6) + α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid, ethyl ester (110862-43-6) → α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid (110862-44-7)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In water;

Reference yield:

α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid, ethyl ester (110862-43-6) → α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid (110862-44-7)

Guidance literature:

With sodium hydroxide; In methanol; water; for 2h; Heating;

DOI:10.1021/jm00105a056

Reference yield:

2-[1,3]dioxolan-2-yl-ethylamine (5754-35-8) → α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid (110862-44-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 82.5 percent / triethylamine / acetonitrile / Ambient temperature

2: triethylamine / CH₂Cl₂ / 1 h / 0 °C

3: NaOH / methanol; H₂O / 2 h / Heating

With sodium hydroxide; triethylamine; In methanol; dichloromethane; water; acetonitrile;

DOI:10.1021/jm00105a056

upstream raw materials:

α-<<2-(1,3-dioxolan-2-yl)ethyl>(2-methyl-1-oxopropyl)amino>-4-fluorobenzeneacetic acid, ethyl ester

2-[1,3]dioxolan-2-yl-ethylamine

methanol hydrate

Downstream raw materials:

atorvastatin lactone

(+/-)-trans-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-<2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-3-carboxamide

5-(4-Fluoro-phenyl)-1-[2-((2R,4S)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

5-(4-Fluoro-phenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid benzyl ester

Refernces

• 1、 -. "Trans-6-[2-(3- or 4-Carboxamido-substituted pyrrol-1-yl)-alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis". . . Retrieved 2008/06/13.