2-(METHYLSULFONYL)-1-PYRIDIN-3-YLETHANONE

Base Information

• Chemical Name: 2-(METHYLSULFONYL)-1-PYRIDIN-3-YLETHANONE
• CAS No.: 27302-95-0
• Molecular Formula: C₈H₉NO₃S
• Molecular Weight: 199.23
• Hs Code.: 2933399090
• Mol file: 27302-95-0.mol

Synonyms:Ketone,(methylsulfonyl)methyl 4-pyridyl (8CI)

Chemical Property of 2-(METHYLSULFONYL)-1-PYRIDIN-3-YLETHANONE

Chemical Property:

• Vapor Pressure: 1.71E-08mmHg at 25°C
• Melting Point: 85-87
• Refractive Index: 1.536
• Boiling Point: 455.8°Cat760mmHg
• PKA: 2.39±0.10(Predicted)
• Flash Point: 229.4°C
• PSA: 72.48000
• Density: 1.313g/cm³
• LogP: 1.38970

Purity/Quality:

98%min ^*data from raw suppliers

2-(Methylsulfonyl)-1-pyridin-4-ylethanone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(METHYLSULFONYL)-1-PYRIDIN-3-YLETHANONE

There total 2 articles about 2-(METHYLSULFONYL)-1-PYRIDIN-3-YLETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

γ-(1-dimethylaminovinyl)pyridine (72990-94-4) + methanesulfonyl chloride (124-63-0) → 2-Methanesulfonyl-1-pyridin-4-yl-ethanone (27302-95-0) + (1,1-Dioxo-3-pyridin-4-yl-1λ6-thietan-3-yl)-dimethyl-amine (86703-41-5)

Guidance literature:

With triethylamine; In dichloromethane; 1.) ice cooling, 1 h; 2.) R_.T_., 2 h; than overnight.;

DOI:10.1007/BF00514462

Reference yield:

→ 2-Methanesulfonyl-1-pyridin-4-yl-ethanone (27302-95-0)

Guidance literature:

Dimethylsulfon, 1) NaH, 2) Methylisonicotinat;

upstream raw materials:

γ-(1-dimethylaminovinyl)pyridine

methanesulfonyl chloride

Refernces