3-Bromomethyl-3-oxetanemethanol

Base Information

• Chemical Name: 3-Bromomethyl-3-oxetanemethanol
• CAS No.: 22633-44-9
• Molecular Formula: C5H9BrO2
• Molecular Weight: 181.029
• Hs Code.: 2932999099
• Mol file: 22633-44-9.mol

Synonyms:3-(Bromomethyl)-3-(hydroxymethyl)oxetane;3-(Bromomethyl)-3-oxetanemethanol;[3-(Bromomethyl)oxetan-3-yl]methanol;

Chemical Property of 3-Bromomethyl-3-oxetanemethanol

Chemical Property:

• Vapor Pressure: 0.00582mmHg at 25°C
• Refractive Index: 1.512
• Boiling Point: 242.4 °C at 760 mmHg
• PKA: 14.58±0.10(Predicted)
• Flash Point: 100.4 °C
• PSA: 29.46000
• Density: 1.598g/cm³
• LogP: 0.39020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(3-(Bromomethyl)oxetan-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 23-26-37-60

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromomethyl-3-oxetanemethanol

There total 3 articles about 3-Bromomethyl-3-oxetanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bis(bromomethyl)bis(hydroxymethyl)methane (3296-90-0) → [3-(bromomethyl)oxetan-3-yl]methanol (22633-44-9)

Guidance literature:

With ethanol; sodium; for 2h; Reflux;

DOI:10.1016/j.tetlet.2010.11.118

Reference yield: 52.0%

→ [3-(bromomethyl)oxetan-3-yl]methanol (22633-44-9)

Guidance literature:

Reference yield:

2,2-bis(bromomethyl)-3-bromo-propan-1-ol (1522-92-5) → 2,6-dioxaspiro<3.3>heptane (174-79-8) + 3,3-bis(bromomethyl)oxetane (2402-83-7) + [3-(bromomethyl)oxetan-3-yl]methanol (22633-44-9)

Guidance literature:

In water; at 70 ℃; pH=7.06; Further Variations:; Temperatures; pH-values; Kinetics;

DOI:10.1021/es0495157

upstream raw materials:

bis(bromomethyl)bis(hydroxymethyl)methane

2,2-bis(bromomethyl)-3-bromo-propan-1-ol

Downstream raw materials:

N-{4-[(7-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)oxetan-3-yl]methyl}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-2-yl}-2-(4-chlorophenyl)acetamide

2-(4-chlorophenyl)-N-{4-[(7-{[3-(hydroxymethyl)oxetan-3-yl]methyl}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)carbonyl]pyridin-2-yl}acetamide

3-hydroxymethyl-3-methylaminomethyloxetane

ethyl 2-(3-(4-((2'-chloro-4'-((3-(hydroxymethyl)oxetan-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate

Refernces

• 1、 -. "SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS". Page/Page column 117; 118. . Retrieved 2018/07/05.
• 2、 -. "NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS". Page/Page column 89. . Retrieved 2013/12/03.