A-(METHYLTHIO)ACETAMIDE

Base Information

• Chemical Name: A-(METHYLTHIO)ACETAMIDE
• CAS No.: 22551-24-2
• Molecular Formula: C3H7NOS
• Molecular Weight: 105.161
• Hs Code.: 2930909090
• Mol file: 22551-24-2.mol

Synonyms:(Methylthio)acetamide;

Chemical Property of A-(METHYLTHIO)ACETAMIDE

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0.0135mmHg at 25°C
• Melting Point: 99-102 °C
• Refractive Index: 1.504
• Boiling Point: 258.8 °C at 760 mmHg
• PKA: 15.65±0.40(Predicted)
• Flash Point: 110.3 °C
• PSA: 68.39000
• Density: 1.132 g/cm³
• LogP: 0.53500
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99%min ^*data from raw suppliers

2-(Methylthio)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of A-(METHYLTHIO)ACETAMIDE

There total 7 articles about A-(METHYLTHIO)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(methylthio)acetyl chloride (35928-65-5) → 2-(methylthio)acetamide (22551-24-2)

Guidance literature:

With ammonia; In diethyl ether; at 0 ℃;

DOI:10.1055/s-1982-29698

Reference yield: 76.2%

methyl 2-(methylthio)acetate (16630-66-3) → 2-(methylthio)acetamide (22551-24-2)

Guidance literature:

With ammonium hydroxide; at 20 - 25 ℃; for 2.25h;

Reference yield:

methylthioacetonitrile (35120-10-6) → 2-(methylthio)acetamide (22551-24-2) + methylsulfanyl-acetic acid (2444-37-3)

Guidance literature:

With potassium phosphate buffer; lyophilized Zea mays nitrilase ZmNIT₂ EC 3.5.5.1; In water; at 30 ℃; for 14h; pH=7.15; Title compound not separated from byproducts;

DOI:10.1016/j.tet.2006.04.069

upstream raw materials:

methylthioacetic acid ethyl ester

Chloroacetamide

sodium thiomethoxide

(methylthio)acetyl chloride

Downstream raw materials:

methylthioacetonitrile

2-(2-Methylene-cyclohexyl)-2-methylsulfanyl-acetamide

3-(methylthio)-4-nitroindolin-2-one

3-Methylthio-5-nitro-2-oxindol

Refernces

• 1、 -. "Process For Preparing A Benzoylbenzeneacetamide Derivative". Page/Page column 6-7. . Retrieved 2009/12/27.
• 2、 Mori, Yuji,Fujiwara, Shigeru,Miyachi, Toshiko,Kitanishi, Hiroyuki,Oya, Masayuki,et al.. "Mass Spectrometry of 2-Alkylthio-2-methylpropanoic Acids and Their Esters and Amides. Structural and Steric Effects on the McLafferty Rearrangement". . p. 1505 - 1517. Retrieved 2007/10/02.