METHYL-2,3,4-TRIMETHOXYPHENYLACETATE

Base Information

• Chemical Name: METHYL-2,3,4-TRIMETHOXYPHENYLACETATE
• CAS No.: 22480-88-2
• Molecular Formula: C12H16 O5
• Molecular Weight: 240.25
• Hs Code.: 2918990090
• Mol file: 22480-88-2.mol

Synonyms:Aceticacid, (2,3,4-trimethoxyphenyl)-, methyl ester (8CI)

Chemical Property of METHYL-2,3,4-TRIMETHOXYPHENYLACETATE

Chemical Property:

• PSA: 53.99000
• LogP: 1.42790

Purity/Quality:

98% ^*data from raw suppliers

Methyl-2,3,4-trimethoxyphenylacetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Methyl 2,3,4-trimethoxyphenyl acetate (cas# 22480-88-2) is a useful intermediate used in the preparation of lespeflorin I1 and psoralidin derivatives with anticancer properties.

Technology Process of METHYL-2,3,4-TRIMETHOXYPHENYLACETATE

There total 4 articles about METHYL-2,3,4-TRIMETHOXYPHENYLACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (2,3,4-trimethoxy-phenyl)-acetic acid (22480-91-7) → methyl 2,3,4-trimethoxyphenylacetate (22480-88-2)

Guidance literature:

With sulfuric acid; for 4h; Reflux;

DOI:10.1016/j.tet.2016.04.066

Reference yield:

2,3,4-trimethoxybenzaldehyde (2103-57-3) → methyl 2,3,4-trimethoxyphenylacetate (22480-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium acetate; acetic anhydride / 100 - 120 °C

2.1: sodium hydroxide / water / 10 h / Reflux

2.2: 15 - 20 °C

3.1: sulfuric acid / 4 h / Reflux

With sulfuric acid; sodium acetate; acetic anhydride; sodium hydroxide; In water;

DOI:10.1016/j.tet.2016.04.066

Reference yield:

2-phenyl-4-(2,3,4-trimethoxy-benzylidene)-4H-oxazol-5-one (22558-28-7) → methyl 2,3,4-trimethoxyphenylacetate (22480-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 10 h / Reflux

1.2: 15 - 20 °C

2.1: sulfuric acid / 4 h / Reflux

With sulfuric acid; sodium hydroxide; In water;

DOI:10.1016/j.tet.2016.04.066

upstream raw materials:

2,3,4-trimethoxybenzaldehyde

methanol

(2,3,4-trimethoxy-phenyl)-acetic acid

2-phenyl-4-(2,3,4-trimethoxy-benzylidene)-4H-oxazol-5-one

Refernces