Guvacoline Hydrobromide

Base Information

• Chemical Name: Guvacoline Hydrobromide
• CAS No.: 17210-51-4
• Molecular Formula: BrH*C₇H₁₁NO₂
• Molecular Weight: 222.082
• DSSTox Substance ID: DTXSID20574157
• Mol file: 17210-51-4.mol

Synonyms:Guvacoline Hydrobromide;17210-51-4;Guvacoline, Hydrobromide;Guvacoline (hydrobromide);methyl 1,2,3,6-tetrahydropyridine-5-carboxylate;hydrobromide;METHYL 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLATE HYDROBROMIDE;Guvacoline (hydrobromide?);SCHEMBL8872254;DTXSID20574157;DOXOETUWVNVADB-UHFFFAOYSA-N;Guvacine methyl ester,hydrobromide;1,2,5,6-Tetrahydronicotinic Acid Methyl Ester Hydrobromide;1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Methyl Ester Hydrobromide;HY-116490;CS-0065632;J-010795;1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester hydrobromide;Methyl 1,2,5,6-tetrahydropyridine-3-carboxylate--hydrogen bromide (1/1)

Chemical Property of Guvacoline Hydrobromide

Chemical Property:

• Melting Point: 144°C
• Storage Temp.: -20°C Freezer
• Solubility.: ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 221.00514
• Heavy Atom Count: 11
• Complexity: 163

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

GuvacolineHydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC(=O)C1=CCCNC1.Br
• Uses: A muscarinic receptor used as nootropic agent.

Technology Process of Guvacoline Hydrobromide

There total 3 articles about Guvacoline Hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

arecoline hydrobromide (300-08-3) → 1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester hydrobromide (17210-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene

2: water / Ambient temperature

With water; In toluene;

Reference yield:

(N-chlorocarbonyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester) (121661-86-7) → 1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester hydrobromide (17210-51-4)

Guidance literature:

With water; Yield given; Ambient temperature;

Reference yield:

→ 1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester hydrobromide (17210-51-4)

Guidance literature:

Vinyloxycarbonylverbindung 3b, Br2, CH2Cl2, MeOH;

DOI:10.1016/S0040-4039(01)93104-1

upstream raw materials:

(N-chlorocarbonyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid methyl ester)

arecoline hydrobromide

Downstream raw materials:

guvacine

1-benzyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester; hydrobromide

N-ethyl-1,2,3,6-tetrahydropyridine-5-carboxylic acid

Refernces

• 1、 Olofson,Schnur,Bunes,Pepe. "Selective N dealkylation of tertiary amines with vinyl chloroformate: An improved synthesis of naloxone". . p. 1567 - 1570. Retrieved 2007/10/08.