1-methoxy-2-(methylsulfonyl)-4-nitrobenzene

Base Information

• Chemical Name: 1-methoxy-2-(methylsulfonyl)-4-nitrobenzene
• CAS No.: 38063-41-1
• Molecular Formula: C₈H₉NO₅S
• Molecular Weight: 231.229
• Mol file: 38063-41-1.mol

Synonyms:1-methoxy-2-(methylsulfonyl)-4-nitrobenzene

Chemical Property of 1-methoxy-2-(methylsulfonyl)-4-nitrobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methoxy-2-(methylsulfonyl)-4-nitrobenzene

There total 13 articles about 1-methoxy-2-(methylsulfonyl)-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.5%

2-methanesulfonyl-4-nitro-phenol (208191-64-4) + methyl iodide (74-88-4) → 1-methoxy-2-(methylsulfonyl)-4-nitrobenzene (38063-41-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

(2-methoxy-5-nitrophenyl)(methyl)sulfane (90005-97-3) → 1-methoxy-2-(methylsulfonyl)-4-nitrobenzene (38063-41-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

1-methoxy-2-(methylsulfanyl)benzene (2388-73-0) → 1-methoxy-2-(methylsulfonyl)-4-nitrobenzene (38063-41-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid anhydride; nitric acid

2: fuming nitric acid / 0 °C

3: potassium dichromate; diluted sulfuric acid

With potassium dichromate; sulfuric acid; nitric acid; acetic anhydride;

DOI:10.1039/jr9262903093

upstream raw materials:

1-methanesulfonyl-2-methoxy-benzene

2-methanesulfinyl-1-methoxy-4-nitro-benzene

dimethyl sulfate

nitric acid

Downstream raw materials:

2-methanesulfonyl-4-nitro-phenol

4-methoxy-3-(methylsulfonyl)aniline

Refernces

• 1、 -. "INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS". Page/Page column 59. . Retrieved 2011/10/13.