Multi-step reaction with 6 steps
1: 1) sodium hydroxide, 30percent hydrogen peroxide / 1) ether, water, 10-25 deg C; 2) ether, 0 deg C
2: 9.83 g / pyridinium p-toluenesulfonate / CH2Cl2 / 4 h / Ambient temperature
3: 8.52 g / lithium diisopropylamide / tetrahydrofuran / 1 h / -78 - -45 °C
4: 5.66 g / pyridinium p-toluenesulfonate / acetone / 7 h / Ambient temperature
5: 3.70 g / pyridinium dichromate, 4-A molecular sieves / ethyl acetate / 22 h
6: 0.62 g / CuI, hexamethylphosphoramide, 4-(dimethylamino)pyridine / tetrahydrofuran / -78 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium hydroxide; copper(l) iodide; dipyridinium dichromate; 4 A molecular sieve; dihydrogen peroxide; pyridinium p-toluenesulfonate; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; ethyl acetate; acetone;