8-ACETOXYQUINALDINE

Base Information

• Chemical Name: 8-ACETOXYQUINALDINE
• CAS No.: 27037-61-2
• Molecular Formula: C12H11 N O2
• Molecular Weight: 201.22
• Hs Code.: 2933499090
• Mol file: 27037-61-2.mol

Synonyms:8-Quinolinol,2-methyl-, acetate (6CI,7CI); 8-Quinolinol, 2-methyl-, acetate (ester)(8CI,9CI); 2-Methyl-8-acetoxyquinoline

Chemical Property of 8-ACETOXYQUINALDINE

Chemical Property:

• Vapor Pressure: 0.000218mmHg at 25°C
• Melting Point: 63-64 °C
• Refractive Index: 1.599
• Boiling Point: 326.3°Cat760mmHg
• PKA: 3.68±0.50(Predicted)
• Flash Point: 151.1°C
• PSA: 39.19000
• Density: 1.178g/cm³
• LogP: 2.46850

Purity/Quality:

98.5% ^*data from raw suppliers

8-ACETOXYQUINALDINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-ACETOXYQUINALDINE

There total 2 articles about 8-ACETOXYQUINALDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methyl-8-quinolinol (826-81-3) + acetic anhydride (108-24-7) → 2‐methyl‐8‐acetoxyquinoline (27037-61-2)

Guidance literature:

for 15h; Heating;

DOI:10.1055/s-1999-3599

Reference yield:

→ 2‐methyl‐8‐acetoxyquinoline (27037-61-2)

Guidance literature:

Reference yield: 85.0%

2‐methyl‐8‐acetoxyquinoline (27037-61-2) → 2-formyl oxine (14510-06-6)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 75 - 80 ℃; for 7h;

DOI:10.1002/bio.3482

upstream raw materials:

2-methyl-8-quinolinol

acetic anhydride

Downstream raw materials:

2-formyl oxine

Refernces

• 1、 Wei, Li-Juan,Gao, Hong-Ling,Cui, Jian-Zhong. "A new 2-((Z)-thiosemicarbazidomethyl)-quinolin-8-YL acetate ligand and its Cu(II) complex: Syntheses, structures, and characterizations". . p. 1101 - 1108. Retrieved 2012.
• 2、 Choudhary, Neha,Dimmling, Alexander,Wang, Xiaozhu,Southcott, Lily,Radchenko, Valery,Patrick, Brian O.,Comba, Peter,Orvig, Chris. "Octadentate oxine-armed bispidine ligand for radiopharmaceutical chemistry". . p. 8685 - 8693. Retrieved 2019.
• 3、 Wu, Yongqiang,Guo, Tiantong,Shu, Dehua,Zhang, Wu,Luan, Fangfei,Shi, Ling,Guo, Dongcai. "Synthesis and luminescence properties of novel 8-hydroxyquinoline derivatives and their Eu(III) complexes". . p. 855 - 862. Retrieved 2018/07/13.