Technology Process of (4R,6R)-6-(benzyloxymethyl)-4-methyltetrahydro-2H-pyran-2-one
There total 5 articles about (4R,6R)-6-(benzyloxymethyl)-4-methyltetrahydro-2H-pyran-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; nickel(II) chloride hexahydrate; boric acid;
In
tetrahydrofuran; water;
at 0 ℃;
for 0.666667h;
diastereoselective reaction;
Cooling;
DOI:10.1134/S1070428014030178
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ammonium chloride; zinc / water; tetrahydrofuran / 1.33 h
2: titanium(IV) isopropylate; trifluoroacetic acid; (R)-1,1'-Bi-2-naphthol / toluene / 168 h / -30 - -15 °C / Molecular sieve
3: nickel(II) chloride hexahydrate; boric acid; sodium tetrahydroborate / water; tetrahydrofuran / 0.67 h / 0 °C / Cooling
With
titanium(IV) isopropylate; sodium tetrahydroborate; nickel(II) chloride hexahydrate; (R)-1,1'-Bi-2-naphthol; boric acid; ammonium chloride; trifluoroacetic acid; zinc;
In
tetrahydrofuran; water; toluene;
1: |Barbier Coupling Reaction / 2: |Keck Asymmetric Allylation;
DOI:10.1134/S1070428014030178
- Guidance literature:
-
Multi-step reaction with 2 steps
1: titanium(IV) isopropylate; trifluoroacetic acid; (R)-1,1'-Bi-2-naphthol / toluene / 168 h / -30 - -15 °C / Molecular sieve
2: nickel(II) chloride hexahydrate; boric acid; sodium tetrahydroborate / water; tetrahydrofuran / 0.67 h / 0 °C / Cooling
With
titanium(IV) isopropylate; sodium tetrahydroborate; nickel(II) chloride hexahydrate; (R)-1,1'-Bi-2-naphthol; boric acid; trifluoroacetic acid;
In
tetrahydrofuran; water; toluene;
1: |Keck Asymmetric Allylation;
DOI:10.1134/S1070428014030178