Technology Process of (E)-8-chloro-4-ethoxy-N-(4-(methylthio)styryl)quinoline-2-carboxamide
There total 6 articles about (E)-8-chloro-4-ethoxy-N-(4-(methylthio)styryl)quinoline-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(I) oxide; caesium carbonate; N,N`-dimethylethylenediamine;
In
tetrahydrofuran;
at 85 ℃;
Inert atmosphere;
DOI:10.1021/jo3025626
- Guidance literature:
-
Multi-step reaction with 5 steps
1: methanol / 4 h / 20 °C
2: polyphosphoric acid / neat (no solvent) / 2 h / 135 °C
3: potassium carbonate / N,N-dimethyl-formamide
4: ammonium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C
5: caesium carbonate; copper(I) oxide; N,N`-dimethylethylenediamine / tetrahydrofuran / 85 °C / Inert atmosphere
With
copper(I) oxide; ammonium hydroxide; water; potassium carbonate; caesium carbonate; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
1: |Michael Addition / 5: |Goldberg Reaction;
DOI:10.1021/jo3025626
- Guidance literature:
-
Multi-step reaction with 4 steps
1: polyphosphoric acid / neat (no solvent) / 2 h / 135 °C
2: potassium carbonate / N,N-dimethyl-formamide
3: ammonium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C
4: caesium carbonate; copper(I) oxide; N,N`-dimethylethylenediamine / tetrahydrofuran / 85 °C / Inert atmosphere
With
copper(I) oxide; ammonium hydroxide; water; potassium carbonate; caesium carbonate; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
4: |Goldberg Reaction;
DOI:10.1021/jo3025626
