METHYL 2-PHENOXYBENZOATE

Base Information

• Chemical Name: METHYL 2-PHENOXYBENZOATE
• CAS No.: 21905-56-6
• Molecular Formula: C14H12 O3
• Molecular Weight: 228.247
• Hs Code.: 2918990090
• Mol file: 21905-56-6.mol

Synonyms:Benzoicacid, o-phenoxy-, methyl ester (8CI); 2-Phenoxybenzoic acid methyl ester;Methyl 2-phenoxybenzoate; Methyl o-phenoxybenzoate

Chemical Property of METHYL 2-PHENOXYBENZOATE

Chemical Property:

• Vapor Pressure: 0.000317mmHg at 25°C
• Refractive Index: 1.5760
• Boiling Point: 320.5°Cat760mmHg
• Flash Point: 131.6°C
• PSA: 35.53000
• Density: 1.153g/cm³
• LogP: 3.26550
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

Benzoicacid,2-phenoxy-,methylester 97% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-Phenoxybenzoate is a useful synthesis intermediate. It is used in the preparation of hydrazides and hydrazones of phenoxy acetic that exhibits analgesic properties.

Technology Process of METHYL 2-PHENOXYBENZOATE

There total 10 articles about METHYL 2-PHENOXYBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

diazomethyl-trimethyl-silane (18107-18-1) + 2-phenoxybenzoic acid (2243-42-7) → methyl 2-phenoxybenzoate (21905-56-6)

Guidance literature:

With methanol; In diethyl ether; toluene; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01233

Reference yield: 75.0%

2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) + methyl salicylate (119-36-8,8024-54-2) → xanth-9-one (90-47-1) + methyl 2-phenoxybenzoate (21905-56-6)

Guidance literature:

With cesium fluoride; In tetrahydrofuran; at 65 ℃; for 24h; Further Variations:; Solvents; Temperatures; Reagents; reaction times; Product distribution;

DOI:10.1021/ol0517731

Reference yield: 75.0%

tert-butyldimethyl(phenoxy)silane (18052-27-2) + o-iodo-methyl-benzoic acid (610-97-9) → methyl 2-phenoxybenzoate (21905-56-6)

Guidance literature:

With oxygen; copper diacetate; caesium carbonate; In N,N-dimethyl-formamide; at 145 ℃; for 18h; under 760.051 Torr;

DOI:10.1039/c9nj01777a

upstream raw materials:

methanol

2-phenoxybenzoic acid

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

methyl salicylate

Downstream raw materials:

benzoic acid methyl ester

benzene

phenol

methyl salicylate

Refernces

• 1、 Ahmed, Muhammad Naeem,Ahmad, Khalil,Yasin, Khawaja Ansar,Farooq, Tayyaba,Khan, Bilal Ahmad,Roy, Soumendra K.. "Ligand-free Cu(ii)-catalyzed aerobic etherification of aryl halides with silanes: An experimental and theoretical approach". . p. 11316 - 11333. Retrieved 2019/07/31.
• 2、 Okita, Toshimasa,Muto, Kei,Yamaguchi, Junichiro. "Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst". supporting information. p. 3132 - 3135. Retrieved 2018/05/28.