Ethanone, 2-chloro-1-(3-methylphenyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 2-chloro-1-(3-methylphenyl)- (9CI)
• CAS No.: 21886-54-4
• Molecular Formula: C9H9 Cl O
• Molecular Weight: 168.623
• Hs Code.: 2914700090
• Mol file: 21886-54-4.mol

Synonyms:Acetophenone,2-chloro-3'-methyl- (7CI,8CI); 2-Chloro-1-(3-methylphenyl)ethanone;2-Chloro-3'-methylacetophenone; m-Methylphenacyl chloride

Chemical Property of Ethanone, 2-chloro-1-(3-methylphenyl)- (9CI)

Chemical Property:

• PSA: 17.07000
• LogP: 2.41650

Purity/Quality:

99% ^*data from raw suppliers

2-chloro-1-m-tolylethanone 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 2-chloro-1-(3-methylphenyl)- (9CI)

There total 13 articles about Ethanone, 2-chloro-1-(3-methylphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(+/-)-2,2,2-trichloro-1-(3-methylphenyl)ethanol (59881-69-5) → 3-methylphenyl chloromethyl ketone (21886-54-4)

Guidance literature:

With [2,2]bipyridinyl; copper(l) chloride; In 1,2-dichloro-ethane; for 3h; Heating;

DOI:10.1021/jo8007644

Reference yield: 90.0%

1-(chloroethynyl)-3-methylbenzene → 3-methylphenyl chloromethyl ketone (21886-54-4)

Guidance literature:

With tetrafluoroboric acid; water; In 2,2,2-trifluoroethanol; at 80 ℃; for 10h;

DOI:10.1016/j.tetlet.2016.09.088

Reference yield: 86.0%

1-(m-methylphenyl)ethanol (7287-81-2,25675-28-9,42070-91-7,51154-53-1) → 3-methylphenyl chloromethyl ketone (21886-54-4)

Guidance literature:

With methanol; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; In dichloromethane; at 20 ℃; for 2h; Reagent/catalyst;

DOI:10.1021/ol5024568

upstream raw materials:

3-methylstyrene

2-Diazo-3'-methylacetophenon

2-bromo-3'-methylacetophenone

(+/-)-2,2,2-trichloro-1-(3-methylphenyl)ethanol

Downstream raw materials:

m-methyl-α-hydroxyacetophenone

2-methoxy-1-(m-tolyl)ethan-1-one

3-(3-methylphenyl)-2H-1,4-benzoxazine

C₁₈H₂₁NO₂

Refernces

• 1、 Rather, Suhail A.,Kumar, Atul,Ahmed, Qazi Naveed. "Iodine-DMSO-promoted divergent reactivities of arylacetylenes". supporting information. p. 4511 - 4514. Retrieved 2019/04/26.
• 2、 Tian, Siyu,Lv, Shide,Jia, Xiaofei,Ma, Li,Li, Baoying,Zhang, Guofeng,Gao, Wei,Wei, Yingqin,Chen, Jianbin. "CV-driven Optimization: Cobalt-Catalyzed Electrochemical Expedient Oxychlorination of Alkenes via ORR". supporting information. p. 5626 - 5633. Retrieved 2019/11/22.