1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran methanesulfonate salt

Base Information

• Chemical Name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran methanesulfonate salt
• CAS No.: 852705-13-6
• Molecular Formula: CH₄O₃S*C₁₉H₂₁BrFNO
• Molecular Weight: 474.391
• Mol file: 852705-13-6.mol

Synonyms:1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran methanesulfonate salt

Chemical Property of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran methanesulfonate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran methanesulfonate salt

There total 1 articles about 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran methanesulfonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(+)-3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine (488148-14-7) + methanesulfonic acid (75-75-2,98527-29-8) → 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran methanesulfonate salt (852705-13-6)

Guidance literature:

In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

Reference yield:

1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran methanesulfonate salt (852705-13-6) + copper(I) cyanide (544-92-3) → escitalopram (128196-01-0)

Guidance literature:

1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-bromo-1,3-dihydroisobenzofuran methanesulfonate salt; copper(I) cyanide; In DMF (N,N-dimethyl-formamide); at 145 - 150 ℃; for 36h;

With ethylenediamine; In DMF (N,N-dimethyl-formamide); water; at 25 - 30 ℃; for 4h; Product distribution / selectivity;

upstream raw materials:

(S)-(+)-3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

methanesulfonic acid

Downstream raw materials:

escitalopram

Refernces