(E)-4-hydroxy-3-methoxybenzaldehyde oxime

Base Information

• Chemical Name: (E)-4-hydroxy-3-methoxybenzaldehyde oxime
• CAS No.: 134283-49-1
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.164
• Mol file: 134283-49-1.mol

Synonyms:(E)-4-hydroxy-3-methoxybenzaldehyde oxime

Chemical Property of (E)-4-hydroxy-3-methoxybenzaldehyde oxime

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-hydroxy-3-methoxybenzaldehyde oxime

There total 4 articles about (E)-4-hydroxy-3-methoxybenzaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

vanillin (121-33-5,8014-42-4) → (E)-4-hydroxy-3-methoxybenzaldehyde oxime (134283-49-1)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate trihydrate; In water; at 80 ℃; for 2h;

DOI:10.1021/acs.jmedchem.8b00734

Reference yield: 96.22%

3-methoxy-4-hydroxybenzaldehyde methyl oxime → N-methoxylamine hydrochloride (593-56-6) + (E)-4-hydroxy-3-methoxybenzaldehyde oxime (134283-49-1)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; water; at 40 ℃;

Reference yield: 91.0%

acetic acid 4-(hydroxyimino-methyl)-2-methoxy-phenyl ester → (E)-4-hydroxy-3-methoxybenzaldehyde oxime (134283-49-1)

Guidance literature:

natural kaolinitic clay; In methanol; at 25 ℃; for 0.5h;

DOI:10.1016/S0040-4039(00)02198-5

upstream raw materials:

vanillin

Downstream raw materials:

vanillylamine hydrochloride

Refernces

• 1、 Schiano Moriello, Aniello,López Chinarro, Silvia,Novo Fernández, Olalla,Eras, Jordi,Amodeo, Pietro,Canela-Garayoa, Ramon,Vitale, Rosa Maria,Di Marzo, Vincenzo,De Petrocellis, Luciano. "Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists". . p. 8255 - 8281. Retrieved 2018/09/25.