METHYL 2'-CHLORO[1,1'-BIPHENYL]-4-CARBOXYLATE

Base Information

• Chemical Name: METHYL 2'-CHLORO[1,1'-BIPHENYL]-4-CARBOXYLATE
• CAS No.: 89900-96-9
• Molecular Formula: C₁₄H₁₁ClO₂
• Molecular Weight: 246.693
• Hs Code.: 2917399590
• Mol file: 89900-96-9.mol

Synonyms:2'-chlorobiphenyl-4-carboxylic acid methyl ester

Chemical Property of METHYL 2'-CHLORO[1,1'-BIPHENYL]-4-CARBOXYLATE

Chemical Property:

Purity/Quality:

Methyl 2'-chloro-1,1'-biphenyl-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2'-CHLORO[1,1'-BIPHENYL]-4-CARBOXYLATE

There total 4 articles about METHYL 2'-CHLORO[1,1'-BIPHENYL]-4-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-methoxycarbonylphenyl bromide (619-42-1) + 2-Chlorobenzeneboronic acid (3900-89-8) → 2'-chlorobiphenyl-4-carboxylic acid methyl ester (89900-96-9)

Guidance literature:

With C₂₀H₁₆N₄O₅^(2-)*Pd⁽²⁺⁾; potassium carbonate; In water; at 70 ℃; for 4h; Reflux;

DOI:10.1039/c5gc01551k

Reference yield: 82.0%

methyl coumalate (6018-41-3) + 2-chlorostyrene (2039-87-4,107830-52-4,26125-41-7) → 2'-chlorobiphenyl-4-carboxylic acid methyl ester (89900-96-9)

Guidance literature:

palladium on activated charcoal; In m-xylene; at 140 ℃; for 10h;

DOI:10.1080/00397919408010254

Reference yield:

chlorobenzene (108-90-7) + methyl 4-formylbenzoate (1571-08-0) → methyl 4′-chloro-[1,1′-biphenyl]-4-carboxylate (89901-02-0) + 2'-chlorobiphenyl-4-carboxylic acid methyl ester (89900-96-9) + methyl 3'-chloro-[1,1'-biphenyl]-4-carboxylate (89901-01-9)

Guidance literature:

With di-tert-butyl peroxide; 1,2-Dinitrobenzene; at 150 ℃; for 12h; Overall yield = 59 %; Overall yield = 29 mg; Inert atmosphere; Sealed tube;

DOI:10.1039/c4cc10155c

upstream raw materials:

methanol

2'-chloro[1,1'-biphenyl]-4-carboxylic acid

methyl coumalate

2-chlorostyrene

Downstream raw materials:

4-(2-chloro-phenyl)-benzaldehyde

2'-chlorobiphenyl-4-ylmethanol

Refernces

• 1、 Zong, Yingxiao,Wang, Junke,He, Yubi,Yue, Guoren,Wang, Xicun,Pan, Yi. "An imidazolium ionic compound-supported palladium complex as an efficient catalyst for Suzuki-Miyaura reactions in aqueous media". . p. 89621 - 89626. Retrieved 2016/10/03.
• 2、 -. "INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS". Page 13. . Retrieved 2010/02/10.