5-AMINO-PYRIDAZINE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-AMINO-PYRIDAZINE-4-CARBOXYLIC ACID
• CAS No.: 21579-37-3
• Molecular Formula: C₅H₅N₃O₂
• Molecular Weight: 139.114
• Hs Code.: 2933990090
• Mol file: 21579-37-3.mol

Synonyms:4-Pyridazinecarboxylicacid,5-amino-(8CI,9CI);

Chemical Property of 5-AMINO-PYRIDAZINE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.663
• Boiling Point: 470.486 °C at 760 mmHg
• Flash Point: 238.342 °C
• PSA: 89.10000
• Density: 1.534 g/cm³
• LogP: 0.33820
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

5-Amino-pyridazine-4-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-PYRIDAZINE-4-CARBOXYLIC ACID

There total 1 articles about 5-AMINO-PYRIDAZINE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-amino-pyridazine-4-carboxylic acid (21579-37-3)

Guidance literature:

Saeure (6) u. KOBr;

Reference yield:

5-amino-pyridazine-4-carboxylic acid (21579-37-3) → C21H21F3N4O3

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 16 h / 0 °C / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 2 h / 25 °C / Inert atmosphere

With sulfuric acid; sodium hydride; In N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jm5010013

Reference yield:

5-amino-pyridazine-4-carboxylic acid (21579-37-3) → 5-((3aR,5r,6aS)-5-(2-(trifluoromethyl)phenyl)octahydrocyclopenta[c]pyrrole-2-ylcarboxamido)pyridazine-4-carboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 16 h / 0 °C / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 2 h / 25 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 3 h / 25 °C / Inert atmosphere

With lithium hydroxide monohydrate; sulfuric acid; sodium hydride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jm5010013

Downstream raw materials:

2-phenyl-pyridazino[4,5-d][1,3]oxazin-4-one