C₅₀H₇₈N₂O₁₀

Base Information

• Chemical Name: C₅₀H₇₈N₂O₁₀
• CAS No.: 1007834-20-9
• Molecular Formula: C₅₀H₇₈N₂O₁₀
• Molecular Weight: 867.177
• Mol file: 1007834-20-9.mol

Synonyms:C₅₀H₇₈N₂O₁₀

Chemical Property of C₅₀H₇₈N₂O₁₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₀H₇₈N₂O₁₀

There total 5 articles about C₅₀H₇₈N₂O₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,12-dodecanedioic acid monobenzyl ester (88353-04-2) + 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (23978-55-4) → C50H78N2O10 (1007834-20-9)

Guidance literature:

1,12-dodecanedioic acid monobenzyl ester; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

1,4,10,13-tetraoxa-7,16-diazacyclooctadecane; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1055/s-0034-1378345

Reference yield:

C19H27ClO3 (158069-69-3) + 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (23978-55-4) → C50H78N2O10 (1007834-20-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.3987/COM-07-S(U)62

Reference yield:

benzyl bromide (100-39-0) → C50H78N2O10 (1007834-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; potassium hydroxide / methanol / Inert atmosphere

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

With tetrabutylammomium bromide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; dichloromethane;

DOI:10.1055/s-0034-1378345

upstream raw materials:

C₁₉H₂₇ClO₃

1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

benzyl bromide

1,12-dodecanedioic acid monobenzyl ester

Refernces

• 1、 Wang, Wei,Yamnitz, Carl R.,Gokel, George W.. "Heterocyclic amide hydraphile synthetic cation transporters". experimental part. p. 825 - 839. Retrieved 2009/09/08.