4-DIMETHYLAMINO-4'-NITROBIPHENYL

Base Information

• Chemical Name: 4-DIMETHYLAMINO-4'-NITROBIPHENYL
• CAS No.: 2143-87-5
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.277
• Hs Code.: 2921499090
• Mol file: 2143-87-5.mol

Synonyms:4-Biphenylamine,N,N-dimethyl-4'-nitro- (6CI,7CI,8CI); 4-(Dimethylamino)-4'-nitrobiphenyl;N,N-Dimethyl-(4'-nitrobiphenyl-4-yl)amine

Chemical Property of 4-DIMETHYLAMINO-4'-NITROBIPHENYL

Chemical Property:

• Vapor Pressure: 1.5E-06mmHg at 25°C
• Melting Point: 243.0 to 249.0 °C
• Refractive Index: 1.618
• Boiling Point: 398.2oC at 760 mmHg
• PKA: 3.97±0.12(Predicted)
• Flash Point: 194.6oC
• PSA: 49.06000
• Density: 1.184g/cm3
• LogP: 3.85100

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Dimethylamino-4’-nitrobiphenyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-DIMETHYLAMINO-4'-NITROBIPHENYL

There total 11 articles about 4-DIMETHYLAMINO-4'-NITROBIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ N,N-dimethyl-4-(4-nitrophenyl)aniline (2143-87-5)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 2.5h;

Reference yield: 88.0%

4-(dimethylamino)benzene-boronic acid (28611-39-4) + para-nitrophenyl bromide (586-78-7) → N,N-dimethyl-4-(4-nitrophenyl)aniline (2143-87-5)

Guidance literature:

With potassium carbonate; In ethanol; water; at 80 ℃; for 0.166667h; Sealed tube; Microwave irradiation; Green chemistry;

DOI:10.1016/j.apcata.2014.11.033

Reference yield: 81.0%

4-bromo-N,N-dimethylaniline (586-77-6) + 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene (171364-83-3) → N,N-dimethyl-4-(4-nitrophenyl)aniline (2143-87-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c2ob07146k

upstream raw materials:

4-amino-4'-nitrobiphenyl

dimethyl sulfate

p-nitrobenzene iodide

(4-(dimethylamino)phenyl)zinc(II) chloride

Downstream raw materials:

bis-(4'-dimethylamino-biphenyl-4-yl)-diazene

Refernces

• 1、 -. "Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof". Paragraph 1814; 1816; 1817; 1842; 1844-1846. . Retrieved 2020/08/28.
• 2、 Elazab, Hany A.,Siamaki, Ali R.,Moussa, Sherif,Gupton, B. Frank,El-Shall, M. Samy. "Highly efficient and magnetically recyclable graphene-supported Pd/Fe3O4 nanoparticle catalysts for Suzuki and Heck cross-coupling reactions". . p. 58 - 69. Retrieved 2015/05/05.