1-benzofuran-3-carboxylic acid

Base Information

• Chemical Name: 1-benzofuran-3-carboxylic acid
• CAS No.: 26537-68-8
• Molecular Formula: C9H6 O3
• Molecular Weight: 162.145
• Hs Code.: 2932999099
• Mol file: 26537-68-8.mol

Synonyms:1-Benzofuran-3-carboxylicacid

Chemical Property of 1-benzofuran-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 9.31E-05mmHg at 25°C
• Melting Point: 162℃
• Refractive Index: 1.649
• Boiling Point: 325.6°Cat760mmHg
• PKA: 3.19±0.10(Predicted)
• Flash Point: 150.7°C
• PSA: 50.44000
• Density: 1.363g/cm³
• LogP: 2.13100
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-benzofuran-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzofuran-3-carboxylic acid

There total 16 articles about 1-benzofuran-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

3-(α-methoxy)methylene benzofuran-2-(3H)-ketone (40800-90-6) → benzofurane-3-carboxylic acid (26537-68-8)

Guidance literature:

With sodium hydroxide; In methanol; at 0 - 60 ℃; Solvent; Reagent/catalyst; Temperature;

Reference yield: 90.0%

C10H6O3 → benzofurane-3-carboxylic acid (26537-68-8)

Guidance literature:

With pyrrolidine; dihydrogen peroxide; In toluene; at 25 ℃; for 2h;

DOI:10.1002/ejoc.201600795

Reference yield: 85.0%

1-benzofuran-2,3-dicarboxylic acid (131-76-0) → benzofurane-3-carboxylic acid (26537-68-8)

Guidance literature:

With acetic acid; silver carbonate; In dimethyl sulfoxide; at 140 ℃; for 16h; regioselective reaction;

DOI:10.1021/ol902482p

upstream raw materials:

3-bromobenzofuran

n-butyllithium

diethyl ether

1-benzofuran-2,3-dicarboxylic acid

Downstream raw materials:

3-acetylbenzo[b]furan

2-hydroxy(phenyl)methylbenzofuran-3-carboxylic acid

2-ethylbenzofuran-3-carboxylic acid

2-methyl-1-benzofuran-3-carboxylic acid

Refernces

• 1、 Gilman,Melstrom. "-". . p. 1655. Retrieved 1948.
• 2、 Khan, Shahnawaz,Ahmed, Qazi Naveed. "2-Oxo-Driven Coupling Reactions of 2-Oxo Aldehydes/2-Oxo Iminium Ions and Hydroperoxides at Room Temperature". . p. 5377 - 5385. Retrieved 2016/11/22.
• 3、 -. "NOVEL INDOL CARBOXYLIC ACID BISPYRIDYL CARBOXAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD AND COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT". Page/Page column 8. . Retrieved 2009/10/21.