N,N-DIMETHYL-3-FLUOROANILINE

Base Information

• Chemical Name: N,N-DIMETHYL-3-FLUOROANILINE
• CAS No.: 2107-43-9
• Molecular Formula: C8H10 F N
• Molecular Weight: 139.173
• Hs Code.: 2921420090
• Mol file: 2107-43-9.mol

Synonyms:Aniline,m-fluoro-N,N-dimethyl- (6CI,7CI,8CI); 3-Fluoro-N,N-dimethylaniline;N,N-Dimethyl-3-fluoroaniline; N,N-Dimethyl-m-fluoroaniline;m-Fluoro-N,N-dimethylaniline

Chemical Property of N,N-DIMETHYL-3-FLUOROANILINE

Chemical Property:

• Vapor Pressure: 0.117mmHg at 25°C
• Refractive Index: 1.537
• Boiling Point: 219.8°C at 760 mmHg
• Flash Point: 99.5°C
• PSA: 3.24000
• Density: 1.083g/cm³
• LogP: 1.89170
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

3-Fluoro-N,N-dimethylaniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DIMETHYL-3-FLUOROANILINE

There total 12 articles about N,N-DIMETHYL-3-FLUOROANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

carbon dioxide (124-38-9,18923-20-1) + 3-fluoro-N-methylaniline (1978-37-6) → N,N-dimethyl 3-fluoroaniline (2107-43-9)

Guidance literature:

With [Ru(Triphos)(TMM)]; hydrogen; bis(trifluoromethanesulfonyl)amide; In tetrahydrofuran; at 150 ℃; for 22h; under 60006 Torr; Inert atmosphere;

Reference yield: 90.0%

3-Dimethylaminophenol (99-07-0) → N,N-dimethyl 3-fluoroaniline (2107-43-9)

Guidance literature:

With 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; cesium fluoride; In 1,4-dioxane; at 110 ℃; for 20h; Product distribution / selectivity; Sealed vial;

Reference yield: 87.0%

3-fluoro-N,N-dimethylaniline oxide → N,N-dimethyl 3-fluoroaniline (2107-43-9)

Guidance literature:

With phenylsilane; In acetonitrile; for 0.166667h; chemoselective reaction; Irradiation;

DOI:10.1002/cphc.202100108

upstream raw materials:

trimethyl phosphite

meta-fluoroaniline

methanol

sodium methylate

Downstream raw materials:

C₂₀H₁₈F₂N₂O₂

2,6-Dichloro-N'-[1-(4-dimethylamino-2-fluoro-phenyl)-meth-(E)-ylidene]-benzene-1,4-diamine

2,6-Dichloro-N'-(4-dimethylamino-2-fluoro-benzyl)-benzene-1,4-diamine

N'-[2,6-Dichloro-4-(4-dimethylamino-2-fluoro-benzylamino)-phenyl]-N,N-dimethyl-formamidine

Refernces

• 1、 Liu, Xiang,Loh, Teck-Peng,Qiang, Wenwen,Wang, Jing,Ye, Sen,Zhu, Longfei. "Additive-freeN-methylation of amines with methanol over supported iridium catalyst". . p. 3364 - 3375. Retrieved 2021/06/06.
• 2、 -. "FLUORINATION OF ORGANIC COMPOUNDS". Paragraph 00207. . Retrieved 2015/05/05.