Technology Process of 8-amino-7-<(6-phenylhexyl)oxy>-4-chromanone
There total 5 articles about 8-amino-7-<(6-phenylhexyl)oxy>-4-chromanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen; triethylamine;
palladium on activated charcoal;
In
1,4-dioxane;
for 24h;
Ambient temperature;
DOI:10.1021/jm00016a021
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 94 percent / HNO3, H2SO4 / 5 h / 0 °C
2: 68 percent / K2CO3, LiI / dimethylformamide / 24 h / 90 °C
3: 67 percent / H2, Et3N / 5percent Pd/C / dioxane / 24 h / Ambient temperature
With
sulfuric acid; hydrogen; nitric acid; potassium carbonate; triethylamine; lithium iodide;
palladium on activated charcoal;
In
1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00016a021
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) Na, 2.) galcial acetic acid, concd. HCl / 1.) ether, 0 deg C to RT, 15 h, ether, 100 deg C, 0.5 h
2: 88 percent / BBr3 / CH2Cl2 / 21 h / -78 - 20 °C
3: 94 percent / HNO3, H2SO4 / 5 h / 0 °C
4: 68 percent / K2CO3, LiI / dimethylformamide / 24 h / 90 °C
5: 67 percent / H2, Et3N / 5percent Pd/C / dioxane / 24 h / Ambient temperature
With
hydrogenchloride; sulfuric acid; hydrogen; nitric acid; sodium; boron tribromide; potassium carbonate; acetic acid; triethylamine; lithium iodide;
palladium on activated charcoal;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00016a021
