Technology Process of 4-(2,3-epoxy-2-fluoropropyl)phenyl acetate
There total 3 articles about 4-(2,3-epoxy-2-fluoropropyl)phenyl acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 65 percent / N-iodosuccinimide, Et3N*3HF / CH2Cl2
2: 58 percent / DBU / benzene / 24 h / Heating
3: 1.) 3-chloroperbenzoic acid, 2.) KF / 1.) CHCl3, 25 deg C, 24 h, 2.) CHCl3, 5 h
With
potassium fluoride; N-iodo-succinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; benzene;
DOI:10.1016/0040-4020(95)01092-0
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 58 percent / DBU / benzene / 24 h / Heating
2: 1.) 3-chloroperbenzoic acid, 2.) KF / 1.) CHCl3, 25 deg C, 24 h, 2.) CHCl3, 5 h
With
potassium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid;
In
benzene;
DOI:10.1016/0040-4020(95)01092-0
- Guidance literature:
-
With
potassium fluoride; 3-chloro-benzenecarboperoxoic acid;
Yield given. Multistep reaction;
1.) CHCl3, 25 deg C, 24 h, 2.) CHCl3, 5 h;
DOI:10.1016/0040-4020(95)01092-0
