[1-(aminomethyl)cyclobutyl]methanol

Base Information

• Chemical Name: [1-(aminomethyl)cyclobutyl]methanol
• CAS No.: 2041-56-7
• Molecular Formula: C6H13 N O
• Molecular Weight: 115.175
• Hs Code.: 2922199090
• Mol file: 2041-56-7.mol

Synonyms:1-Hydroxymethyl-1-cyclobutylmethylamine

Chemical Property of [1-(aminomethyl)cyclobutyl]methanol

Chemical Property:

• Vapor Pressure: 0.117mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 194.229°C at 760 mmHg
• PKA: 15.05±0.10(Predicted)
• Flash Point: 71.268°C
• PSA: 46.25000
• Density: 1.022g/cm³
• LogP: 0.80800

Purity/Quality:

99%, ^*data from raw suppliers

[1-(Aminomethyl)cyclobutyl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (1-(Aminomethyl)cyclobutyl)methanol is a building block used in the preparation of isoquinoline and pyrido[3,4-d]pyrimidine derivatives as Mps1 inhibitors.

Technology Process of [1-(aminomethyl)cyclobutyl]methanol

There total 2 articles about [1-(aminomethyl)cyclobutyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 1-cyano-1-cyclobutanecarboxylate (28246-87-9) → [1-(aminomethyl)cyclobutyl]methanol (2041-56-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating;

DOI:10.1021/jm00280a001

Reference yield:

→ [1-(aminomethyl)cyclobutyl]methanol (2041-56-7)

Guidance literature:

1-Cyan-cyclobutancarbonsaeure-aethylester, LiAlH4, Ae.;

Reference yield: 58.0%

[1-(aminomethyl)cyclobutyl]methanol (2041-56-7) + 3-chloro-4-(2,6-difluoro-4-isothiocyanatophenoxy)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine → N-{4-[(3-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3,5-difluorophenyl}-N'-{[1-(hydroxymethyl)cyclobutyl]methyl}thiourea

Guidance literature:

In N,N-dimethyl-formamide; at 50 ℃; for 3h;

upstream raw materials:

ethyl 1-cyano-1-cyclobutanecarboxylate

Downstream raw materials:

N-(1-chloromethyl-cyclobutylmethyl)-4-methyl-benzenesulfonamide

2-azaspiro[3.3]heptane

2-(2-aza-spiro[3.3]hept-2-yl)-ethanol

C₂₄H₂₄ClN₃O₃

Refernces

• 1、 Newman,Broger,LaPidus,Tye. "Investigation of the gem-Dialkyl effect in medicinal agents.". . p. 1003 - 1006. Retrieved 2007/10/05.