2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER
• CAS No.: 2040-44-0
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Hs Code.: 2918990090
• Mol file: 2040-44-0.mol

Synonyms:Propionic acid,2-(benzyloxy)-, ethyl ester (8CI);2-(Benzyloxy)propanoic acid ethyl ester;2-Benzyloxypropionic acid ethyl ester;

Chemical Property of 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 294.9 °C at 760 mmHg
• Flash Point: 102.8 °C
• PSA: 35.53000
• Density: 1.049 g/cm³
• LogP: 2.15480

Purity/Quality:

99% ^*data from raw suppliers

racEthyl2-(Benzyloxy)propionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER is used in the process for preparation of optically active 2-hydroxypropoxyaniline derivatives as intermediates for Levofloxacin via enzymic or microbial stereoselective hydrolysis of racemic lactic acid ester.

Technology Process of 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER

There total 7 articles about 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethyl 2-hydroxypropionate (97-64-3,2676-33-7) + benzyl bromide (100-39-0) → ethyl 2-benzyloxypropionate (2040-44-0)

Guidance literature:

With caesium carbonate; In dichloromethane; for 5h; Heating;

DOI:10.1016/S0040-4039(99)00083-0

Reference yield: 60.0%

benzyl alcohol (100-51-6,185532-71-2) + ethyl 2-benzoylpropionate (10488-87-6) → ethyl 2-benzyloxypropionate (2040-44-0)

Guidance literature:

With 4-toluenesulfonyl azide; tetra(trifluoroacetamidato)dirhodium(II); caesium carbonate; In dichloromethane; Heating;

DOI:10.1021/ol040039z

Reference yield:

ethyl (S)-2-(benzyloxy)propionate (54783-72-1) → ethyl 2-benzyloxypropionate (2040-44-0)

Guidance literature:

ethyl (S)-2-(benzyloxy)propionate; With sodium ethanolate; In toluene; at 20 ℃; for 14h;

With citric acid; In water; toluene;

upstream raw materials:

ethyl 2-hydroxypropionate

benzyl bromide

Ethyl 2-bromopropionate

benzyl alcohol

Downstream raw materials:

4-Benzyloxy-1-hydroxy-pentan-3-one

2-(benzyloxy)propanoic acid

(((3-methylbut-3-en-2-yl)oxy)methyl)benzene

3-(phenylmethoxy)butan-2-one

Refernces

• 1、 Brodsky, Benjamin H.,Du Bois. "Deacylative oxidation strategy for the preparation of α- functionalized carbonyls". . p. 2619 - 2621. Retrieved 2007/10/03.
• 2、 Dueno,Chu,Kim,Kyung Woon Jung. "Cesium promoted O-alkylation of alcohols for the efficient ether synthesis". . p. 1843 - 1846. Retrieved 2007/10/03.