1,4-Diazobicylco[3.2.2]nonane

Base Information

• Chemical Name: 1,4-Diazobicylco[3.2.2]nonane
• CAS No.: 283-38-5
• Molecular Formula: C7H14N2
• Molecular Weight: 126.202
• Hs Code.: 2933990090
• Mol file: 283-38-5.mol

Synonyms:1,4-Diaza-bicyclo[3.2.2]nonane;

Chemical Property of 1,4-Diazobicylco[3.2.2]nonane

Chemical Property:

• Boiling Point: 180 °C at 760 mmHg
• PKA: 11.00±0.20(Predicted)
• Flash Point: 71.9 °C
• PSA: 15.27000
• Density: 1.03 g/cm³
• LogP: 0.32070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

1,4-Diazabicyclo[3.2.2]nonane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Diazobicylco[3.2.2]nonane

There total 8 articles about 1,4-Diazobicylco[3.2.2]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,4-diaza-bicyclo[3.2.2]nonan-3-one (53619-11-7) → 1,4-diazabicyclo[3.2.2]nonane (283-38-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1080/00397910500377255

Reference yield: 76.0%

1,4-diazabicyclo[3.2.2]nonane dihydrochloride (150208-70-1) → 1,4-diazabicyclo[3.2.2]nonane (283-38-5)

Guidance literature:

With water; sodium hydroxide; at 17 ℃; pH=Ca. 13;

Reference yield: 13.3%

→ 1-(2-fluoroethyl)-6,8-difluoro-1,4-dihydro-7-(1,4-diazabicyclo[3.2.2]non-4-yl)-4-oxo-3-quinoline carboxylic acid (112894-32-3) + 1,4-diazabicyclo[3.2.2]nonane (283-38-5)

Guidance literature:

upstream raw materials:

1,4-diaza-bicyclo[3.2.2]nonan-3-one

3-quinuclidone oxime

3-quinuclidinone hydrochloride

1,4-diazabicyclo[3.2.2]nonane dihydrochloride

Downstream raw materials:

SSR₁₈₀₇₁₁ hydrochloride

4-[5-(2-phenoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1,4-diazabicyclo[3.2.2]nonane

N-Methyl-N-phenyl-1,4-diazabicyclo[3.2.2]-nonane-4-carboxamide hydrobromide

N-Phenyl-1,4-diazabicyclo[3.2.2]nonane-4-carboxamide hydrobromide

Refernces

• 1、 Shao, Hao,Foley, David W.,Huang, Shiliang,Abbas, Abdullahi Y.,Lam, Frankie,Gershkovich, Pavel,Bradshaw, Tracey D.,Pepper, Chris,Fischer, Peter M.,Wang, Shudong. "Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents". supporting information. . Retrieved 2021/02/16.
• 2、 -. "Glucosylceramide synthase inhibitors". Page/Page column 51. . Retrieved 2015/09/28.