6-chloro-2-phenylthiomethylpyridine

Base Information

• Chemical Name: 6-chloro-2-phenylthiomethylpyridine
• CAS No.: 460720-22-3
• Molecular Formula: C₁₂H₁₀ClNS
• Molecular Weight: 235.737
• Mol file: 460720-22-3.mol

Synonyms:6-chloro-2-phenylthiomethylpyridine

Chemical Property of 6-chloro-2-phenylthiomethylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-2-phenylthiomethylpyridine

There total 2 articles about 6-chloro-2-phenylthiomethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

sodium thiophenolate (930-69-8) + 6-chloro-2-chloromethylpyridine (78846-88-5) → 6-chloro-2-phenylthiomethylpyridine (460720-22-3)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1.5h;

DOI:10.1016/S0022-328X(02)01145-2

Reference yield:

6-chloro-2-pyridinemethanol (33674-97-4) → 6-chloro-2-phenylthiomethylpyridine (460720-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: 90 percent / KOH / dimethylsulfoxide / 1.5 h / 20 °C

With potassium hydroxide; thionyl chloride; In dimethyl sulfoxide;

DOI:10.1016/S0022-328X(02)01145-2

Reference yield: 92.0%

sodium perchlorate monohydrate (7791-07-3) + [PdCl(η(3)-CH2C(Me)C(Me)2)]2 + 6-chloro-2-phenylthiomethylpyridine (460720-22-3) → [Pd(η3-1,1,2-Me3C3H2)(6-chloro-2-phenylthiomethylpyridine)](ClO4) (460720-37-0)

Guidance literature:

In methanol; dichloromethane; stirred at room temp. under N2 for 1 h; evapd. in vacuo, residue dissolved in CH2Cl2, treated with activated charcoal, filtered through celite, filtrate was concd., treated with Et2O, ppt. was collected; elem. anal.;

DOI:10.1016/S0022-328X(02)01145-2

upstream raw materials:

sodium thiophenolate

6-chloro-2-chloromethylpyridine

6-chloro-2-pyridinemethanol

Downstream raw materials:

[Pd(η3-1,1,2,3,3-Me5C3)(6-chloro-2-phenylthiomethylpyridine)](ClO4)

[Pd(η3-1,1,2-Me3C3H2)(6-chloro-2-phenylthiomethylpyridine)](ClO4)

[Pd(η2-tetramethylethylentetracarboxylate)(6-chloro-2-phenylthiomethylpyridine)]

[Pd(C₄(CO₂Me)4)(6-chloro-2-phenylthiomethylpyridine)]

Refernces