4-AMINO-N-(3-TRIFLUOROMETHYL-PHENYL)-BENZENESULFONAMIDE

Base Information

• Chemical Name: 4-AMINO-N-(3-TRIFLUOROMETHYL-PHENYL)-BENZENESULFONAMIDE
• CAS No.: 339-40-2
• Molecular Formula: C13H11 F3 N2 O2 S
• Molecular Weight: 316.304
• Hs Code.: 2935009090
• Mol file: 339-40-2.mol

Synonyms:m-Sulfanilotoluidide, a,a,a-trifluoro- (7CI,8CI); NSC 30666

Chemical Property of 4-AMINO-N-(3-TRIFLUOROMETHYL-PHENYL)-BENZENESULFONAMIDE

Chemical Property:

• Vapor Pressure: 8.79E-08mmHg at 25°C
• Boiling Point: 435.4°Cat760mmHg
• Flash Point: 217.1°C
• PSA: 80.57000
• Density: 1.475g/cm³
• LogP: 4.82340

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-N-[3-(trifluoromethyl)-phenyl]benzenesulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-N-(3-TRIFLUOROMETHYL-PHENYL)-BENZENESULFONAMIDE

There total 9 articles about 4-AMINO-N-(3-TRIFLUOROMETHYL-PHENYL)-BENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(4-{[3-(trifluoromethyl)phenyl]sulfamoyl}phenyl)acetamide → 4-amino-N-[3-(trifluoromethyl)phenyl]benzene-1-sulfonamide (339-40-2)

Guidance literature:

With hydrogenchloride; In acetone; at 20 ℃; for 0.0833333h; Cooling with ice;

DOI:10.1016/j.bmcl.2017.08.012

Reference yield: 41.83%

4-nitro-N-(3-(trifluoromethyl)phenyl)benzenesulfonamide (2927-97-1) → 4-amino-N-[3-(trifluoromethyl)phenyl]benzene-1-sulfonamide (339-40-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 6h; under 3102.97 Torr;

DOI:10.1016/j.ejmech.2014.04.025

Reference yield:

3-trifluoromethylaniline (98-16-8) + p-acetylaminobenzenesulfonyl chloride (121-60-8) → 4-amino-N-[3-(trifluoromethyl)phenyl]benzene-1-sulfonamide (339-40-2)

Guidance literature:

With pyridine; Erwaermen des Reaktionsprodukts mit wss. Natronlauge;

DOI:10.1021/ja01200a513

upstream raw materials:

3-trifluoromethylaniline

p-acetylaminobenzenesulfonyl chloride

3-trifluoromethylnitrobenzene

4-Nitrobenzenesulfonyl chloride

Downstream raw materials:

1,3-diethyl 2-(((4-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)phenyl)amino)methylene)malonate

N-cyclohexyl-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide

4-oxo-N-(pyridin-3-ylmethyl)-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide

N-(furan-2-ylmethyl)-4-oxo-6-(N-(3-(trifluoromethyl)phenyl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide

Refernces

• 1、 Wang, Xu,Ahn, Yong-Mo,Lentscher, Adam G.,Lister, Julia S.,Brothers, Robert C.,Kneen, Malea M.,Gerratana, Barbara,Boshoff, Helena I.,Dowd, Cynthia S.. "Design, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD+) synthetase inhibitors as potential antitubercular agents". supporting information. p. 4426 - 4430. Retrieved 2017/09/12.
• 2、 Liu, Peng,Niu, Yan,Wang, Chao,Sun, Qi,Zhai, Yaya,Yu, Jiapei,Sun, Jing,Xu, Fengrong,Yan, Gang,Huang, Wenjie,Liang, Lei,Xu, Ping. "4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: Synthesis, biological evaluation and docking studies". . p. 413 - 421. Retrieved 2014/05/06.