1H-PYRROLO[2,3-F]QUINOLINE

Base Information

• Chemical Name: 1H-PYRROLO[2,3-F]QUINOLINE
• CAS No.: 233-36-3
• Molecular Formula: C₁₁H₈N₂
• Molecular Weight: 168.198
• Hs Code.: 2933990090
• Mol file: 233-36-3.mol

Synonyms:1,6-Diaza-1H-benz[e]indene

Chemical Property of 1H-PYRROLO[2,3-F]QUINOLINE

Chemical Property:

• Melting Point: 235-240 °C
• PSA: 28.68000
• LogP: 2.71610

Purity/Quality:

98% ^*data from raw suppliers

1H-Pyrrolo[2,3-f]quinoline 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Useful fused pyridino-indole for pharmaceutical research.

Technology Process of 1H-PYRROLO[2,3-F]QUINOLINE

There total 14 articles about 1H-PYRROLO[2,3-F]QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

trans-2-[β-(dimethylamino)vinyl]-5-nitroquinoline → 1H-pyrrolo[2,3-f]quinoline (233-36-3)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; dichloromethane; at 20 ℃;

DOI:10.1039/b313012f

Reference yield: 63.0%

2-carboxy-1H-pyrrolo<2,3-f>quinoline (63385-12-6) → 1H-pyrrolo[2,3-f]quinoline (233-36-3)

Guidance literature:

With copper; In solid; Heating;

Reference yield: 60.0%

(5-Nitro-6-quinolinyl)acetonitrile (105199-23-3) → 1H-pyrrolo[2,3-f]quinoline (233-36-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; acetic acid; at 20 ℃; for 2h; under 2585.74 Torr;

upstream raw materials:

2-carboxy-1H-pyrrolo<2,3-f>quinoline

5-nitroquinoline

vinyl magnesium bromide

(5-Nitro-6-quinolinyl)acetonitrile

Downstream raw materials:

1-tosyl-1H-pyrrolo[2,3-f]quinoline-3-carbaldehyde

(1-tosyl-1H-pyrrolo[2,3-f]quinolin-3-yl)methanol

3-(chloromethyl)-1-tosyl-1H-pyrrolo[2,3-f]quinoline

3-(((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl)methyl)-1-tosyl-1H-pyrrolo[2,3-f] quinoline

Refernces

• 1、 Grychowska, Katarzyna,Kurczab, Rafa?,?liwa, Pawe?,Sata?a, Grzegorz,Dubiel, Krzysztof,Mat?oka, Miko?aj,Moszczyński-P?tkowski, Rafa?,Pieczykolan, Jerzy,Bojarski, Andrzej J.,Zajdel, Pawe?. "Pyrroloquinoline scaffold-based 5-HT6R ligands: Synthesis, quantum chemical and molecular dynamic studies, and influence of nitrogen atom position in the scaffold on affinity". . p. 3588 - 3595. Retrieved 2018/05/31.
• 2、 Vlachou, Margarita,Tsotinis, Andrew,Kelland, Lloyd R.,Thurston, David E.. "A new ring-forming methodology for the synthesis of bioactive pyrroloquinoline derivatives". . p. 129 - 133. Retrieved 2007/10/03.