N-carbobenzyloxy-L-prolyl-L-proline p-nitrophenyl ester

Base Information

• Chemical Name: N-carbobenzyloxy-L-prolyl-L-proline p-nitrophenyl ester
• CAS No.: 107164-47-6
• Molecular Formula: C₂₄H₂₅N₃O₇
• Molecular Weight: 467.478
• Mol file: 107164-47-6.mol

Synonyms:N-carbobenzyloxy-L-prolyl-L-proline p-nitrophenyl ester

Chemical Property of N-carbobenzyloxy-L-prolyl-L-proline p-nitrophenyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-carbobenzyloxy-L-prolyl-L-proline p-nitrophenyl ester

There total 2 articles about N-carbobenzyloxy-L-prolyl-L-proline p-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-L-proline p-nitrophenyl ester (3304-59-4) → N-carbobenzyloxy-L-prolyl-L-proline p-nitrophenyl ester (107164-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr / acetic acid / 2 h / Ambient temperature

2: 1.) ethyl chloroformate, 2.) triethylamine / 1.) methylene chloride, -10 deg C, 2.) -5 deg C, 2 h, rt 3 h

With hydrogen bromide; chloroformic acid ethyl ester; triethylamine; In acetic acid;

DOI:10.1021/ja00248a038

Reference yield:

L-proline p-nitrophenyl ester hydrogen bromide (2390-84-3) + N-Benzyloxycarbonyl-L-proline (1148-11-4) → N-carbobenzyloxy-L-prolyl-L-proline p-nitrophenyl ester (107164-47-6)

Guidance literature:

With chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1.) methylene chloride, -10 deg C, 2.) -5 deg C, 2 h, rt 3 h;

DOI:10.1021/ja00248a038

upstream raw materials:

L-proline p-nitrophenyl ester hydrogen bromide

N-Benzyloxycarbonyl-L-proline

N-benzyloxycarbonyl-L-proline p-nitrophenyl ester

Refernces