Technology Process of 3-(3-phenylqinolin-2-yl)azetidine-1-carboxylate tert-butyl ester
There total 3 articles about 3-(3-phenylqinolin-2-yl)azetidine-1-carboxylate tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; water;
at 80 ℃;
for 12h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: chloro-trimethyl-silane; zinc; ethylene dibromide / dimethyl amine / 1 h / 20 °C / Inert atmosphere
1.2: 16 h / 80 °C / Inert atmosphere
2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 12 h / 80 °C / Inert atmosphere
With
chloro-trimethyl-silane; sodium carbonate; ethylene dibromide; zinc;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; water; dimethyl amine;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: chloro-trimethyl-silane; zinc; ethylene dibromide / dimethyl amine / 1 h / 20 °C / Inert atmosphere
1.2: 16 h / 80 °C / Inert atmosphere
2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 12 h / 80 °C / Inert atmosphere
With
chloro-trimethyl-silane; sodium carbonate; ethylene dibromide; zinc;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; water; dimethyl amine;
