6-FLUORO-2-METHYLQUINAZOLIN-4(3H)-ONE

Base Information

• Chemical Name: 6-FLUORO-2-METHYLQUINAZOLIN-4(3H)-ONE
• CAS No.: 194473-04-6
• Molecular Formula: C9H7 F N2 O
• Molecular Weight: 178.166
• Mol file: 194473-04-6.mol

Synonyms:4(1H)-Quinazolinone,6-fluoro-2-methyl- (9CI); 6-Fluoro-2-methylquinazolin-4-one

Chemical Property of 6-FLUORO-2-METHYLQUINAZOLIN-4(3H)-ONE

Chemical Property:

• Refractive Index: 1.619
• PSA: 45.75000
• Density: 1.37
• LogP: 1.37060

Purity/Quality:

98%min ^*data from raw suppliers

6-Fluoro-2-methylquinazolin-4-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-FLUORO-2-METHYLQUINAZOLIN-4(3H)-ONE

There total 6 articles about 6-FLUORO-2-METHYLQUINAZOLIN-4(3H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-Bromo-5-fluorobenzoic acid (394-28-5) + acetamidine hydrochloride (124-42-5) → 6-fluoro-2-methylquinazolin-4(3H)-one (194473-04-6)

Guidance literature:

With C₂₆H₂₄Cu₂N₈⁽²⁺⁾*2F₆P^(1-); caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 6h; Inert atmosphere; Sealed tube;

DOI:10.1002/aoc.3177

Reference yield: 92.0%

5-fluoro-2-iodobenzoic acid (52548-63-7) + acetamidine hydrochloride (124-42-5) → 6-fluoro-2-methylquinazolin-4(3H)-one (194473-04-6)

Guidance literature:

With sodium carbonate; In water; isopropyl alcohol; at 90 ℃; for 12h; Sealed tube; Inert atmosphere;

Reference yield: 74.52%

→ 6-fluoro-2-methylquinazolin-4(3H)-one (194473-04-6)

Guidance literature:

With ammonium acetate; at 150 ℃; for 0.5h;

upstream raw materials:

5-fluoro-anthranilamide hydrochloride

acetic anhydride

2-Bromo-5-fluorobenzoic acid

acetamidine hydrochloride

Refernces

• 1、 -. "Method for preparing quinazolone and derivatives thereof by using chitosan-loaded copper catalyst". Paragraph 0108-0114. . Retrieved 2021/05/12.
• 2、 Baska, Ferenc,Sipos, Anna,?rfi, Zoltán,Nemes, Zoltán,Dobos, Judit,Szántai-Kis, Csaba,Szabó, Eszter,Szénási, Gábor,Dézsi, László,Hamar, Péter,Cserepes, Mihály T.,Tóvári, József,Garamv?lgyi, Rita,Krekó, Marcell,?rfi, László. "Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases". supporting information. . Retrieved 2019/10/16.