5-hydroxyhexanal

Base Information

• Chemical Name: 5-hydroxyhexanal
• CAS No.: 143956-84-7
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.16
• Mol file: 143956-84-7.mol

Synonyms:5-hydroxyhexanal

Chemical Property of 5-hydroxyhexanal

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-hydroxyhexanal

There total 3 articles about 5-hydroxyhexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hexane-1,5-diol (928-40-5) → 5-oxohexanal (505-03-3) + 5-hydroxyhexanal (143956-84-7) + 6-hydroxy-2-hexanone (21856-89-3)

Guidance literature:

With sodium acetate; 4,7-di-(NaSO₃Ph)-[1.10]phenanthroline-Pd(OAc)2; In water; at 100 ℃; under 22502.3 Torr; pH=6.5; Product distribution; Kinetics;

DOI:10.1002/1615-4169(200206)344:3/4<355::AID-ADSC355>3.0.CO;2-S

Reference yield:

hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2) → 1,6-hexanediol (629-11-8) + 5-hydroxyhexanal (143956-84-7)

Guidance literature:

With Li⁽¹⁺⁾*C₁₂H₂₈AlO₃^(1-); In tetrahydrofuran; hexane; at -78 ℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00184a010

Reference yield:

hexane-1,5-diol (928-40-5) → 5-hydroxyhexanal (143956-84-7) + 6-hydroxy-2-hexanone (21856-89-3)

Guidance literature:

With C₁₄H₃₆Cu₂N₄O₂⁽²⁺⁾*2CF₃O₃S^(1-); triethylamine; In dichloromethane; at -80.16 ℃; for 3h; regioselective reaction;

DOI:10.1016/j.ica.2018.11.027

upstream raw materials:

hexahydro-2H-oxepin-2-one

hexane-1,5-diol

Downstream raw materials:

(-)-phoracantholide-J

(R)-(-)-phoracantholide I

(+)-Diplodiaalide A

Refernces

• 1、 Ten Brink, Gerd-Jan,Arends, Isabel W. C. E.,Sheldon, Roger A.. "Catalytic Conversions in Water. Part 21: Mechanistic Investigations on the Palladium-Catalysed Aerobic Oxidation of Alcohols in Water". . p. 355 - 369. Retrieved 2007/10/03.