2-(quinolin-3-yl)isoindoline-1,3-dione

Base Information

• Chemical Name: 2-(quinolin-3-yl)isoindoline-1,3-dione
• CAS No.: 41314-24-3
• Molecular Formula: C₁₇H₁₀N₂O₂
• Molecular Weight: 274.279
• Mol file: 41314-24-3.mol

Synonyms:2-(quinolin-3-yl)isoindoline-1,3-dione

Chemical Property of 2-(quinolin-3-yl)isoindoline-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(quinolin-3-yl)isoindoline-1,3-dione

There total 1 articles about 2-(quinolin-3-yl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-aminoquinoline (580-17-6) + phthalic anhydride (85-44-9) → 2-(quinolin-3-yl)isoindoline-1,3-dione (41314-24-3)

Guidance literature:

With niobium(V) oxide; In hexane; for 30h; Inert atmosphere; Reflux;

DOI:10.1002/chem.201404538

Reference yield: 88.0%

(triphenylphosphine)gold(I) chloride (14243-64-2) + silver trifluoromethanesulfonate (2923-28-6) + 2-(quinolin-3-yl)isoindoline-1,3-dione (41314-24-3) → [Au(PPh3)(3-amino-N-phthalimido-quinoline)](OTf) (1191083-57-4)

Guidance literature:

In dichloromethane; byproducts: AgCl; CH2Cl2 was degassed by bubbling N2 for 10 min, cooled to 0°C, Au-complex and Ag-salt were added, the mixt. was stirred for 10 min, pyridine-compound was slowly added, the mixt. was stirred in the absence of light for 2 h; filtered, the solvent was removed in vac., vapor diffusion of diethyl ether into CHCl3;

DOI:10.1039/b905123f

upstream raw materials:

3-aminoquinoline

phthalic anhydride

Downstream raw materials:

[Au(PPh₃)(3-amino-N-phthalimido-quinoline)](OTf)

Refernces

• 1、 Ali, Md. Ayub,Siddiki, S. M. A. Hakim,Kon, Kenichi,Hasegawa, Junya,Shimizu, Kenichi. "Versatile and sustainable synthesis of cyclic imides from dicarboxylic acids and amines by Nb2O5 as a base-tolerant heterogeneous lewis acid catalyst". supporting information. p. 14256 - 14260. Retrieved 2015/01/09.