Technology Process of (S)-2-(Acryloyl-benzyl-amino)-4-oxo-butyric acid methyl ester
There total 6 articles about (S)-2-(Acryloyl-benzyl-amino)-4-oxo-butyric acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: SOCl2 / Ambient temperature
2: n-Bu3SnH, (Ph3P)4Pd / tetrahydrofuran / Ambient temperature
3: p-TSA / methanol / Heating
4: 84 percent / H2 / 5percent Pd/C / methanol / 2068.6 Torr / Ambient temperature
5: Et3N / CH2Cl2 / Ambient temperature
6: 10percent aq. HCl / CH2Cl2; H2O / Ambient temperature
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; hydrogen; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(00)78176-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: p-TSA / methanol / Heating
2: 84 percent / H2 / 5percent Pd/C / methanol / 2068.6 Torr / Ambient temperature
3: Et3N / CH2Cl2 / Ambient temperature
4: 10percent aq. HCl / CH2Cl2; H2O / Ambient temperature
With
hydrogenchloride; hydrogen; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(00)78176-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1: n-Bu3SnH, (Ph3P)4Pd / tetrahydrofuran / Ambient temperature
2: p-TSA / methanol / Heating
3: 84 percent / H2 / 5percent Pd/C / methanol / 2068.6 Torr / Ambient temperature
4: Et3N / CH2Cl2 / Ambient temperature
5: 10percent aq. HCl / CH2Cl2; H2O / Ambient temperature
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); hydrogen; tri-n-butyl-tin hydride; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(00)78176-7