1-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]cyclopropane carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]cyclopropane carboxylic acid ethyl ester
• CAS No.: 958378-22-8
• Molecular Formula: C₁₈H₂₂O₅
• Molecular Weight: 318.37
• Mol file: 958378-22-8.mol

Synonyms:1-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]cyclopropane carboxylic acid ethyl ester

Chemical Property of 1-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]cyclopropane carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]cyclopropane carboxylic acid ethyl ester

There total 2 articles about 1-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]cyclopropane carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-(2-ethoxycarbonylacetyl)phenyl]-2-methylpropionic acid methyl ester (958378-19-3) + ethylene dibromide (106-93-4) → 1-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]cyclopropane carboxylic acid ethyl ester (958378-22-8)

Guidance literature:

With potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride; In dimethyl sulfoxide; at 20 - 60 ℃; for 5h; Product distribution / selectivity;

Reference yield:

→ 1-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]cyclopropane carboxylic acid ethyl ester (958378-22-8)

Guidance literature:

With morpholine; N-benzyl-N,N,N-triethylammonium chloride; potassium iodide; In dimethyl sulfoxide; at 40 - 50 ℃; for 5h;

With hydrogenchloride; In water; toluene; Purification / work up;

Reference yield:

1-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]cyclopropane carboxylic acid ethyl ester (958378-22-8) + C18H21NO (115-46-8) → 4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]-2-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]butyric acid ethyl ester (958378-24-0)

Guidance literature:

In dimethyl sulfoxide; at 60 - 65 ℃; for 48 - 55h; Product distribution / selectivity;

upstream raw materials:

2-[4-(2-ethoxycarbonylacetyl)phenyl]-2-methylpropionic acid methyl ester

ethylene dibromide

Downstream raw materials:

4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]-2-[4-(1-methoxycarbonyl-1-methylethyl)benzoyl]butyric acid ethyl ester

Refernces