Technology Process of (R)-N-(1-(2-chlorophenyl)ethyl)benzamide
There total 4 articles about (R)-N-(1-(2-chlorophenyl)ethyl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
benzoic acid anhydride;
With
4-(N,N-dipropylamino)pyridine;
In
toluene;
at -78 - 20 ℃;
for 0.25h;
Molecular sieve;
Inert atmosphere;
With
C24H18F12N2OS;
In
toluene;
for 0.25h;
Inert atmosphere;
1-(2-Chloro-phenyl)-ethylamine;
In
toluene;
at -78 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/ol301155b
- Guidance literature:
-
Multi-step reaction with 3 steps
1: [RhCl2(p-cymene)]2; potassium tert-butylate; 2-Amino-2-methyl-1-propanol; isopropyl alcohol / 2 h / 50 °C / Inert atmosphere; Molecular sieve
2: hydrogenchloride / methanol / 20 °C
3: sodium hydroxide / dichloromethane; water / 3 h / 0 - 20 °C
With
hydrogenchloride; [RhCl2(p-cymene)]2; potassium tert-butylate; 2-Amino-2-methyl-1-propanol; isopropyl alcohol; sodium hydroxide;
In
methanol; dichloromethane; water;
DOI:10.1002/chem.201102426
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride / methanol / 20 °C
2: sodium hydroxide / dichloromethane; water / 3 h / 0 - 20 °C
With
hydrogenchloride; sodium hydroxide;
In
methanol; dichloromethane; water;
DOI:10.1002/chem.201102426
