1-(4-chlorophenyl)-1,3-dihydroisobenzofuran

Base Information

• Chemical Name: 1-(4-chlorophenyl)-1,3-dihydroisobenzofuran
• CAS No.: 1599446-28-2
• Molecular Formula: C₁₄H₁₁ClO
• Molecular Weight: 230.694
• Mol file: 1599446-28-2.mol

Synonyms:1-(4-chlorophenyl)-1,3-dihydroisobenzofuran

Chemical Property of 1-(4-chlorophenyl)-1,3-dihydroisobenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-1,3-dihydroisobenzofuran

There total 4 articles about 1-(4-chlorophenyl)-1,3-dihydroisobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-(4-chlorophenyl)-1,2-benzenedimethanol (57591-00-1) → 1-(4-chlorophenyl)-1,3-dihydroisobenzofuran (1599446-28-2)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 3h; Reflux;

DOI:10.1016/j.cclet.2014.01.017

Reference yield:

4-chlorobenzoic acid hydrazide (536-40-3) → 1-(4-chlorophenyl)-1,3-dihydroisobenzofuran (1599446-28-2)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 0.25 h / 20 °C

2: lead(IV) tetraacetate / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

3: sodium tetrahydroborate; pyridine / methanol / 5 h / 20 °C

4: toluene-4-sulfonic acid / toluene / 3 h / Reflux

With pyridine; sodium tetrahydroborate; lead(IV) tetraacetate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; toluene;

DOI:10.1016/j.cclet.2014.01.017

Reference yield:

4-chloro-N’-(2-hydroxybenzylidene)benzohydrazide (100622-79-5) → 1-(4-chlorophenyl)-1,3-dihydroisobenzofuran (1599446-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: lead(IV) tetraacetate / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

2: sodium tetrahydroborate; pyridine / methanol / 5 h / 20 °C

3: toluene-4-sulfonic acid / toluene / 3 h / Reflux

With pyridine; sodium tetrahydroborate; lead(IV) tetraacetate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; toluene;

DOI:10.1016/j.cclet.2014.01.017

upstream raw materials:

4-chlorobenzoic acid hydrazide

4-chloro-N’-(2-hydroxybenzylidene)benzohydrazide

2-(4-chlorobenzoyl)-benzaldehyde

α-(4-chlorophenyl)-1,2-benzenedimethanol

Refernces