2-(3-benzoylphenyl)propionic acid 2-hydroxyethyl ester

Base Information

• Chemical Name: 2-(3-benzoylphenyl)propionic acid 2-hydroxyethyl ester
• CAS No.: 70125-82-5
• Molecular Formula: C₁₈H₁₈O₄
• Molecular Weight: 298.339
• Mol file: 70125-82-5.mol

Synonyms:2-(3-benzoylphenyl)propionic acid 2-hydroxyethyl ester

Chemical Property of 2-(3-benzoylphenyl)propionic acid 2-hydroxyethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-benzoylphenyl)propionic acid 2-hydroxyethyl ester

There total 2 articles about 2-(3-benzoylphenyl)propionic acid 2-hydroxyethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

m-benzoylhydratropic acid sodium salt (57495-14-4) → 2-(3-benzoylphenyl)propionic acid 2-hydroxyethyl ester (70125-82-5)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃; for 24h;

DOI:10.1021/js970465w

Reference yield: 80.0%

ketoprofen (22071-15-4,22161-86-0) + 2-bromoethanol (540-51-2) → 2-(3-benzoylphenyl)propionic acid 2-hydroxyethyl ester (70125-82-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1021/jm701175d

Reference yield: 94.0%

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + 2-(3-benzoylphenyl)propionic acid 2-hydroxyethyl ester (70125-82-5) → (S)-2-tert-butoxycarbonylamino-4-methylpentanoic acid 2-[2-(3-benzoylphenyl)propionyloxy]ethyl ester (1005840-43-6)

Guidance literature:

With dicyclohexyl-carbodiimide; dmap; In dichloromethane; at 20 ℃;

DOI:10.1021/jm701175d

upstream raw materials:

m-benzoylhydratropic acid sodium salt

ketoprofen

2-bromoethanol

Downstream raw materials:

ketoprofen

(S)-2-tert-butoxycarbonylamino-4-methylpentanoic acid 2-[2-(3-benzoylphenyl)propionyloxy]ethyl ester

(S)-2-tert-butoxycarbonylamino-3-phenylpropionic acid 2-[2-(3-benzoylphenyl)propionyloxy]ethyl ester

Refernces

• 1、 Rautio, Jarkko. "In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen". . p. 1622 - 1628. Retrieved 2007/10/03.