Technology Process of 3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide
There total 6 articles about 3-(4-(3-(4-chloro-2-fluorophenoxy)azetidin-1-yl)-1,3,5-triazin-2-ylamino)-5-fluoro-N-methylbenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
isopropyl alcohol;
at 80 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trifluoroacetic acid; water; sulfuric acid / 24 h / 70 °C
2: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
3: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / 760.05 Torr / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / 80 °C
With
sulfuric acid; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
palladium 10% on activated carbon;
In
ethanol; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C / Sealed tube
2: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / 760.05 Torr / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / 80 °C
With
hydrogen; N-ethyl-N,N-diisopropylamine; HATU;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;