Technology Process of 4,4’-dichloro-2-iodobiphenyl
There total 1 articles about 4,4’-dichloro-2-iodobiphenyl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / toluene; water; ethanol / 24 h / 96 °C / Inert atmosphere
2.1: hydrogenchloride; sodium nitrite / water; tetrahydrofuran / 1.33 h / 0 °C / Inert atmosphere
2.2: 12 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); sodium nitrite;
In
tetrahydrofuran; ethanol; water; toluene;
2.1: |Sandmeyer Reaction / 2.2: |Sandmeyer Reaction;
DOI:10.1002/anie.201803603
- Guidance literature:
-
With
potassium acetate; palladium diacetate;
In
N,N-dimethyl-formamide;
at 120 ℃;
for 12h;
DOI:10.1021/acscatal.1c00975
- Guidance literature:
-
With
potassium acetate; palladium diacetate; potassium carbonate; tris-(o-tolyl)phosphine;
In
dimethyl sulfoxide;
at 110 ℃;
for 6h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/acs.orglett.1c01888
