Technology Process of 5-(Phenylsulfonyl)-6-oxo-5,6,7,8-tetrahydroquinoline
There total 10 articles about 5-(Phenylsulfonyl)-6-oxo-5,6,7,8-tetrahydroquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran; dimethyl sulfoxide;
for 1h;
Ambient temperature;
DOI:10.1021/jo00323a016
- Guidance literature:
-
Multi-step reaction with 8 steps
1: azobis(isobutyronitrile), NBS / CCl4 / 1.5 h / Heating; Irradiation
2: 58 percent / ethanol / 1 h / Heating
3: aq. NaIO4 / methanol / 6 h / Ambient temperature
4: KMnO4 / methanol; H2O / 0.5 h / Ambient temperature
5: 84 percent / NBS, azobis(isobutyronitrile) / CCl4 / 2 h / Heating; Irradiation
6: 1.) LDA, HMPT, 2.) / 1.) THF, 0 deg C, 1 h, 2.) -78 deg C, 0.5 h
7: Raney nickel / ethanol; acetone / 1 h / 60 °C
8: 81 percent / sodium hydride / tetrahydrofuran; dimethylsulfoxide / 1 h / Ambient temperature
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium permanganate; sodium periodate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); nickel; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; dimethyl sulfoxide; acetone;
DOI:10.1021/jo00323a016
- Guidance literature:
-
Multi-step reaction with 8 steps
1: PBr3 / diethyl ether / 1 h
2: 58 percent / ethanol / 1 h / Heating
3: aq. NaIO4 / methanol / 6 h / Ambient temperature
4: KMnO4 / methanol; H2O / 0.5 h / Ambient temperature
5: 84 percent / NBS, azobis(isobutyronitrile) / CCl4 / 2 h / Heating; Irradiation
6: 1.) LDA, HMPT, 2.) / 1.) THF, 0 deg C, 1 h, 2.) -78 deg C, 0.5 h
7: Raney nickel / ethanol; acetone / 1 h / 60 °C
8: 81 percent / sodium hydride / tetrahydrofuran; dimethylsulfoxide / 1 h / Ambient temperature
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium permanganate; sodium periodate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); phosphorus tribromide; nickel; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; water; dimethyl sulfoxide; acetone;
DOI:10.1021/jo00323a016