3-Bromobenzyl-acetohydroxamic acid

Base Information

• Chemical Name: 3-Bromobenzyl-acetohydroxamic acid
• CAS No.: 1228680-89-4
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.088
• Mol file: 1228680-89-4.mol

Synonyms:3-Bromobenzyl-acetohydroxamic acid

Chemical Property of 3-Bromobenzyl-acetohydroxamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Bromobenzyl-acetohydroxamic acid

There total 3 articles about 3-Bromobenzyl-acetohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.9%

E-3-bromo-benzaldehyde-oxime (52739-46-5) + sodium carbonate (497-19-8) → 3-Bromobenzyl-acetohydroxamic acid (1228680-89-4)

Guidance literature:

With acetic anhydride; sodium cyanoborohydride;

Reference yield:

3-(m-bromophenyl)propionyl chloride (335159-82-5) → 3-Bromobenzyl-acetohydroxamic acid (1228680-89-4)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In dichloromethane; water; ethyl acetate; at 0 - 20 ℃; for 12h;

DOI:10.1021/acs.orglett.1c00781

Reference yield:

3-(3-bromophenyl)propanoic acid (42287-90-1) → 3-Bromobenzyl-acetohydroxamic acid (1228680-89-4)

Guidance literature:

3-(3-bromophenyl)propanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 25 ℃; for 1h;

With hydroxylamine hydrochloride; for 16h;

DOI:10.1002/anie.201808892

upstream raw materials:

E-3-bromo-benzaldehyde-oxime

sodium carbonate

3-(3-bromophenyl)propanoic acid

3-(m-bromophenyl)propionyl chloride

Downstream raw materials:

8-bromo-3,4-dihydroquinolin-2(1H)-one

6-bromo-3,4-dihydro-1H-quinolin-2-one

Refernces

• 1、 Hwang, Yeongyu,Park, Yoonsu,Kim, Yeong Bum,Kim, Dongwook,Chang, Sukbok. "Revisiting Arene C(sp2)?H Amidation by Intramolecular Transfer of Iridium Nitrenoids: Evidence for a Spirocyclization Pathway". supporting information. p. 13565 - 13569. Retrieved 2018/09/25.