Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 150 °C
2: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr / Inert atmosphere
3: acetonitrile; water; methanol
4: potassium phosphate / copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / tetrahydrofuran / 3 h / 140 °C / Inert atmosphere; Microwave irradiation
5: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 14 h / 100 °C / Inert atmosphere; Sealed vessel
6: hydrogenchloride / ethanol; water / 2 h / 100 °C
With
hydrogenchloride; potassium phosphate; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine;
trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;