Pyrimidine, 2-chloro-4-ethyl- (9CI)

Base Information

• Chemical Name: Pyrimidine, 2-chloro-4-ethyl- (9CI)
• CAS No.: 188707-99-5
• Molecular Formula: C6H7 Cl N2
• Molecular Weight: 142.588
• Hs Code.: 2933599090
• Mol file: 188707-99-5.mol

Synonyms:Pyrimidine, 2-chloro-4-ethyl- (9CI)

Chemical Property of Pyrimidine, 2-chloro-4-ethyl- (9CI)

Chemical Property:

• PSA: 25.78000
• LogP: 1.69240

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-ethylpyrimidine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 2-chloro-4-ethyl- (9CI)

There total 8 articles about Pyrimidine, 2-chloro-4-ethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + propionic acid (802294-64-0,79-09-4) → 2-chloro-4-ethylpyrimidine (188707-99-5)

Guidance literature:

With dipotassium peroxodisulfate; silver nitrate; In dichloromethane; water; at 20 ℃; for 12h;

DOI:10.1039/c4ob02524e

Reference yield: 35.0%

2,6-Dichloropyrimidine (3934-20-1) + ethylmagnesium bromide (925-90-6) → 2-chloro-4-ethylpyrimidine (188707-99-5)

Guidance literature:

With iron(III)-acetylacetonate; In tetrahydrofuran; at -78 ℃; for 0.333333h;

DOI:10.1021/ja2058583

Reference yield: 25.0%

2,6-Dichloropyrimidine (3934-20-1) + triethylaluminum (97-93-8) → 2-chloropyrimidine (1722-12-9,1195939-87-7) + 2-chloro-4-ethylpyrimidine (188707-99-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 24h; Heating;

DOI:10.3891/acta.chem.scand.51-0302

upstream raw materials:

2,6-Dichloropyrimidine

triethylaluminum

4-ethyl-2-ethylmercapto-pyrimidine

4-ethyl-2-ethylsulfanyl-6-chloro-pyrimidine

Downstream raw materials:

C₂₂H₁₇N₅O

N-(2-ethylphenyl)-5-[(4-ethylpyrimidin-2-yl)amino]-3-methyl-1,2-thiazole-4-carboxamide

4-ethylpyrimidin-2-amine

Refernces

• 1、 -. "DIAZASPIROALKANEONE-SUBSTITUTED OXAZOLE DERIVATIVES AS SPLEEN TYROSINE KINASE INHIBITORS". Page/Page column 39. . Retrieved 2015/12/08.
• 2、 Jorgensen, William L.,Bollini, Mariela,Thakur, Vinay V.,Domaoal, Robert A.,Spasov, Krasimir A.,Anderson, Karen S.. "Efficient discovery of potent anti-HIV agents targeting the Tyr181Cys variant of HIV reverse transcriptase". supporting information; experimental part. p. 15686 - 15696. Retrieved 2011/12/03.